AIM: To investigate the expression and significance of heat shock protein 70 (HSP70) and glucose-regulated protein 94 (grp94) in human esophageal carcinoma and adjacent normal tissues. METHODS: The expression of HSP70 and grp94 in 78 human esophageal cancer and adjacent normal tissues was studied by immunohistochemistry and pathology photograph analysis. RESULTS: Both esophageal cancer and adjacent normal tissues could express HSP70 and grp94. Of the 78 cases of esophageal carcinoma, 95.0%(72/78) showed positive HSP70, mainly stained in nuclei, while grp94 was mainly stained in cell plasma, and the positive rate was 71.8%(56/78). There was a significant difference in the expression of HSP70 and grp94 between esophageal cancer and adjacent normal tissues (P<0.01). Compared with adjacent normal tissues, there was a significant difference between differential types and HSP70 expression (P<0.01). CONCLUSION: HSP70 and grp94 express differently in cell plasma and nuclei. The expression intensity of HSP70 is related to the differentiation of esophageal carcinoma.
AIM: To investigate the expression and significance of heat shock protein 70 (HSP70) and glucose-regulated protein 94 (grp94) in humanesophageal carcinoma and adjacent normal tissues. METHODS: The expression of HSP70 and grp94 in 78 humanesophageal cancer and adjacent normal tissues was studied by immunohistochemistry and pathology photograph analysis. RESULTS: Both esophageal cancer and adjacent normal tissues could express HSP70 and grp94. Of the 78 cases of esophageal carcinoma, 95.0%(72/78) showed positive HSP70, mainly stained in nuclei, while grp94 was mainly stained in cell plasma, and the positive rate was 71.8%(56/78). There was a significant difference in the expression of HSP70 and grp94 between esophageal cancer and adjacent normal tissues (P<0.01). Compared with adjacent normal tissues, there was a significant difference between differential types and HSP70 expression (P<0.01). CONCLUSION:HSP70 and grp94 express differently in cell plasma and nuclei. The expression intensity of HSP70 is related to the differentiation of esophageal carcinoma.
Authors: A Nakai; T Kawatani; S Ohi; H Kawasaki; T Yoshimori; Y Tashiro; Y Miyata; I Yahara; M Satoh; K Nagata Journal: Cell Struct Funct Date: 1995-02 Impact factor: 2.212
Authors: Edward W Howard; Steve C L Leung; H F Yuen; Chee Wai Chua; Davy T Lee; K W Chan; Xianghong Wang; Yong Chuan Wong Journal: Clin Exp Metastasis Date: 2008-03-14 Impact factor: 5.150
Authors: H Nomura; K Uzawa; Y Yamano; K Fushimi; T Ishigami; Y Kato; K Saito; D Nakashima; M Higo; Y Kouzu; K Ono; K Ogawara; M Shiiba; H Bukawa; H Yokoe; H Tanzawa Journal: Br J Cancer Date: 2007-08-28 Impact factor: 7.640