| Literature DB >> 12957361 |
Hajime Isomoto1, Mikio Oka, Yoshitsugu Yano, Yusei Kanazawa, Hiroshi Soda, Ryusuke Terada, Toru Yasutake, Toshiyuki Nakayama, Saburo Shikuwa, Fuminao Takeshima, Heiichiro Udono, Ikuo Murata, Kenzo Ohtsuka, Shigeru Kohno.
Abstract
Heat shock proteins (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. We determined the expression of Hsp 70 and Hsp 40 in 81 gastric cancers. Immunoreactivities to Hsp 70 and Hsp 40 were detected in 67.9 and 22.2% of tumors, respectively. Immunohistochemical analysis showed enhanced Hsp 70 and Hsp 40 expression in gastric tumor tissue, relative to the surrounding normal tissue. Overexpression of Hsp 70 and Hsp 40 was also confirmed by immunoblotting. Among various clinicopathological parameters, low histopathological differentiation was associated with reduced expression of both proteins.Entities:
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Year: 2003 PMID： 12957361 DOI： 10.1016/s0304-3835(03)00305-7
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679