Literature DB >> 15635187

Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica.

Miyako Yoshida1, Masahiro Fuchigami, Tsuneatsu Nagao, Hikaru Okabe, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karube, Ryota Tsuchihashi, Junei Kinjo, Kunihide Mihashi, Toshihiro Fujioka.   

Abstract

The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated. Activity-guided fractionation of MeOH extract resulted in the isolation of ursolic acid lactone, ursolic acid, pomolic acid, 2alpha,3alpha-dihydroxyurs-12-en-28-oic acid, 3-epimaslinic acid, asiatic acid, corosolic acid, and rosmarinic acid. Antiproliferative activity of the isolated compounds against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma (B16F10) cells was estimated.

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Year:  2005        PMID： 15635187     DOI： 10.1248/bpb.28.173

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  18 in total

Review 1.  Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise.

Authors:  Mohamed Fizur Nagoor Meeran; Sameer N Goyal; Kapil Suchal; Charu Sharma; Chandragouda R Patil; Shreesh K Ojha
Journal:  Front Pharmacol       Date:  2018-09-04       Impact factor: 5.810

2.  Adriamycin induced myocardial failure in rats: protective role of Centella asiatica.

Authors:  A Gnanapragasam; S Yogeeta; R Subhashini; K K Ebenezar; V Sathish; T Devaki
Journal:  Mol Cell Biochem       Date:  2006-06-20       Impact factor: 3.396

3.  Centella asiatica - Phytochemistry and mechanisms of neuroprotection and cognitive enhancement.

Authors:  Nora E Gray; Armando Alcazar Magana; Parnian Lak; Kirsten M Wright; Joseph Quinn; Jan F Stevens; Claudia S Maier; Amala Soumyanath
Journal:  Phytochem Rev       Date:  2017-09-20       Impact factor: 5.374

4.  Apoptosis induction of Centella asiatica on human breast cancer cells.

Authors:  Suboj Babykutty; Jose Padikkala; Priya Prasanna Sathiadevan; Vinod Vijayakurup; Thasni Karedath Abdul Azis; Priya Srinivas; Srinivas Gopala
Journal:  Afr J Tradit Complement Altern Med       Date:  2008-10-25

Review 5.  Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants.

Authors:  Karma Yeshi; Gerry Turpin; Tenzin Jamtsho; Phurpa Wangchuk
Journal:  Molecules       Date:  2022-06-15       Impact factor: 4.927

6.  Pomolic acid induces apoptosis in SK-OV-3 human ovarian adenocarcinoma cells through the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways.

Authors:  Ki Hyun Yoo; Jong-Hwa Park; DO Kyung Lee; Yuan Yuan Fu; Nam In Baek; In Sik Chung
Journal:  Oncol Lett       Date:  2012-10-22       Impact factor: 2.967

7.  Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties.

Authors:  Andrew T Nelson; Andrew M Camelio; Karin R Claussen; Jiyoon Cho; Lisa Tremmel; John DiGiovanni; Dionicio Siegel
Journal:  Bioorg Med Chem Lett       Date:  2015-07-22       Impact factor: 2.823

8.  Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential.

Authors:  Ilkay Erdogan Orhan
Journal:  Evid Based Complement Alternat Med       Date:  2012-05-14       Impact factor: 2.629

9.  Rosmarinus officinalis leaves as a natural source of bioactive compounds.

Authors:  Isabel Borrás-Linares; Zorica Stojanović; Rosa Quirantes-Piné; David Arráez-Román; Jaroslava Švarc-Gajić; Alberto Fernández-Gutiérrez; Antonio Segura-Carretero
Journal:  Int J Mol Sci       Date:  2014-11-10       Impact factor: 5.923

10.  Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia.

Authors:  Rajanikant G Krishnamurthy; Marie-Claude Senut; Daniel Zemke; Jiangyong Min; Mark B Frenkel; Eric J Greenberg; Seong-Woon Yu; Nick Ahn; John Goudreau; Mounzer Kassab; Kiran S Panickar; Arshad Majid
Journal:  J Neurosci Res       Date:  2009-08-15       Impact factor: 4.164
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