Literature DB >> 15627040

Impact of African herbal medicines on antiretroviral metabolism.

Edward Mills1, Brian C Foster, Rolf van Heeswijk, Elizabeth Phillips, Kumanan Wilson, Blair Leonard, Kazuhiro Kosuge, Isadore Kanfer.   

Abstract

We examined the effects of two African herbal medicines recommended for HIV/AIDS patients on antiretroviral metabolism. Extracts from Hypoxis and Sutherlandia showed significant effects on cytochrome P450 3A4 metabolism and activated the pregnane X receptor approximately twofold. P-glycoprotein expression was inhibited, with Hypoxis showing 42-51% and Sutherlandia showing 19-31% of activity compared with verapamil. Initiating policies to provide herbal medicines with antiretroviral agents may put patients at risk of treatment failure, viral resistance or drug toxicity.

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Year:  2005        PMID： 15627040     DOI： 10.1097/00002030-200501030-00013

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  28 in total

Review 1.  Pregnane X receptor and natural products: beyond drug-drug interactions.

Authors:  Jeff L Staudinger; Xunshan Ding; Kristin Lichti
Journal:  Expert Opin Drug Metab Toxicol       Date:  2006-12       Impact factor: 4.481

2.  Sutherlandia frutescens: the meeting of science and traditional knowledge.

Authors:  Oluwaseyi M Aboyade; Gustav Styger; Diana Gibson; Gail Hughes
Journal:  J Altern Complement Med       Date:  2013-07-09       Impact factor: 2.579

3.  Role of complimentary therapy for male LUTS.

Authors:  Philippa J Cheetham
Journal:  Curr Urol Rep       Date:  2013-12       Impact factor: 3.092

Review 4.  Pharmacokinetic optimization of antiretroviral therapy in children and adolescents.

Authors:  Michael N Neely; Natella Y Rakhmanina
Journal:  Clin Pharmacokinet       Date:  2011-03       Impact factor: 6.447

Review 5.  A global perspective on complementary and alternative medicine use among people living with HIV/AIDS in the era of antiretroviral treatment.

Authors:  Rae A Littlewood; Peter A Vanable
Journal:  Curr HIV/AIDS Rep       Date:  2011-12       Impact factor: 5.071

6.  Social and behavioral factors associated with failing second-line ART - results from a cohort study at the Themba Lethu Clinic, Johannesburg, South Africa.

Authors:  Denise Evans; Sara Dahlberg; Rebecca Berhanu; Tembeka Sineke; Caroline Govathson; Ingrid Jonker; Elisabet Lönnermark; Matthew P Fox
Journal:  AIDS Care       Date:  2018-02-21

7.  Concurrent use of Antiretroviral and African traditional medicines amongst people living with HIV/AIDS (PLWA) in the eThekwini Metropolitan area of KwaZulu Natal.

Authors:  Sibanda Mncengeli; Nlooto M Manimbulu; Naidoo Panjasaram
Journal:  Afr Health Sci       Date:  2016-12       Impact factor: 0.927

8.  "Our hands are tied up": current state of safer conception services suggests the need for an integrated care model.

Authors:  Kathy Goggin; Deborah Mindry; Jolly Beyeza-Kashesya; Sarah Finocchario-Kessler; Rhoda Wanyenze; Christine Nabiryo; Glenn Wagner
Journal:  Health Care Women Int       Date:  2014-08-08

9.  Medical pluralism on Mfangano Island: use of medicinal plants among persons living with HIV/AIDS in Suba District, Kenya.

Authors:  Jason M Nagata; Alan R Jew; John M Kimeu; Charles R Salmen; Elizabeth A Bukusi; Craig R Cohen
Journal:  J Ethnopharmacol       Date:  2011-03-31       Impact factor: 4.360

10.  Knowledge, beliefs, and health care practices relating to treatment of HIV in Vellore, India.

Authors:  Anne Marie Belz Chomat; Ira B Wilson; Christine A Wanke; A Selvakumar; K R John; Rita Isaac
Journal:  AIDS Patient Care STDS       Date:  2009-06       Impact factor: 5.078
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