Literature DB >> 15624934

Preparation of tertiary alkyl carbinamines, propargylamines, and alpha-heteroarylamines by ketone-based aminoalkylation.

Alan R Katritzky1, Hongfang Yang, Sandeep K Singh.   

Abstract

Ketones 6a-i were converted into their benzotriazolylamine adducts 8a-i either directly from the corresponding ketone 6a or via enamines 7b-i. Adducts 8a-i on treatment with Grignard reagents, lithium phenylacetylide, or heteroaryllithiums gave tertiary alkyl carbinamines 9a-h (47-61%), propargylamines 10a-i (30-98%), and alpha-heteroarylamines 11a-k (44-85%), respectively.

Entities:  

Year:  2005        PMID： 15624934     DOI： 10.1021/jo048541k

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  Crystal structure of tert-butyl 4-[4-(4-fluoro-phen-yl)-2-methyl-but-3-yn-2-yl]piperazine-1-carboxyl-ate.

Authors:  Ashwini Gumireddy; Kevin DeBoyace; Alexander Rupprecht; Mohit Gupta; Saloni Patel; Patrick T Flaherty; Peter L D Wildfong
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2021-03-05

2.  Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

Authors:  Stephen Patterson; Deuan C Jones; Emma J Shanks; Julie A Frearson; Ian H Gilbert; Paul G Wyatt; Alan H Fairlamb
Journal:  ChemMedChem       Date:  2009-08       Impact factor: 3.466

3.  Crystal structure of the 1,3,6,8-tetra-aza-tri-cyclo[4.3.1.1(3,8)]undecane (TATU)-4-nitro-phenol (1/2) adduct: the role of anomeric effect in the formation of a second hydrogen-bond inter-action.

Authors:  Augusto Rivera; Héctor Jairo Osorio; Juan Manuel Uribe; Jaime Ríos-Motta; Michael Bolte
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-10-24
  3 in total

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