| Literature DB >> 1562470 |
S Battersby1, B J Robertson, T J Anderson, R J King, K McPherson.
Abstract
Steroid receptor was assessed immunohistochemically in 158 samples of normal breast for variation through the menstrual cycle. Patterns and intensity of reaction were used in a semi-quantitative scoring system to examine the influence of cycle phase, cycle type, parity and age. The changes in oestrogen receptor for natural cycle and oral contraceptive (OC) cycles indicated down-regulation by progestins. Progesterone receptor did not vary significantly in natural cycles, but increased steadily through OC cycles. This study provides strong evidence that both oestrogen and progesterone influence breast epithelium, but dissimilarities from the endometrium are apparent. The interval since pregnancy had a significant negative effect on frequency and score of oestrogen receptor and score of progesterone receptor. Multivariate analysis established the phase of cycle and OC use as independent significant influences on oestrogen receptor. The interval since pregnancy was an independent significant factor for both oestrogen and progesterone receptor presence.Entities:
Keywords: Biology; Clinical Research; Contraception; Contraceptive Methods; Contraceptive Usage; Cytologic Effects; Cytology; Demographic Factors; Developed Countries; Endocrine System; England; Estrogens; Europe; Family Planning; Fertility; Fertility Measurements; Histochemical Effects; Histology; Hormone Receptors; Hormones; Mammary Gland Effects; Membrane Proteins; Menstrual Cycle; Menstruation; Northern Europe; Oral Contraceptives; Parity; Physiology; Population; Population Dynamics; Postpartum Women; Progestational Hormones; Progesterone; Puerperium; Reproduction; Research Methodology; Research Report; United Kingdom
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Year: 1992 PMID： 1562470 PMCID： PMC1977560 DOI： 10.1038/bjc.1992.122
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640