Literature DB >> 15619962

Genetic mapping and ENU mutagenesis.

David R Beier1, Bruce J Herron.   

Abstract

ENU mutagenesis is a potent means to generate novel mutations in the mouse, and the further investigation of these mutations can be logistically demanding. Determination of the map position of a mutation early in its characterization can be extremely useful. We describe how the use of interval haplotype analysis can facilitate this with even small numbers of affected progeny.

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Year:  2004        PMID： 15619962     DOI： 10.1007/s10709-004-1437-5

Source DB:  PubMed          Journal:  Genetica        ISSN： 0016-6707            Impact factor:   1.082


  11 in total

1.  Genetic background modulates behavioral impairments in R6/2 mice and suggests a role for dominant genetic modifiers in Huntington’s disease pathogenesis.

Authors:  Randi-Michelle Cowin; Nghiem Bui; Deanna Graham; Jennie R Green; Lisa A Yuva-Paylor; Andreas Weiss; Richard Paylor
Journal:  Mamm Genome       Date:  2012-06       Impact factor: 2.957

2.  A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice.

Authors:  Christopher B Geyer; Amy L Inselman; Jeffrey A Sunman; Sheila Bornstein; Mary Ann Handel; Edward M Eddy
Journal:  Dev Biol       Date:  2009-03-31       Impact factor: 3.582

Review 3.  Controlling complexity: the clinical relevance of mouse complex genetics.

Authors:  Klaus Schughart; Claude Libert; Martien J Kas
Journal:  Eur J Hum Genet       Date:  2013-05-01       Impact factor: 4.246

Review 4.  Zebrafish as a model to investigate CNS myelination.

Authors:  Marnie A Preston; Wendy B Macklin
Journal:  Glia       Date:  2014-09-27       Impact factor: 7.452

5.  Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish.

Authors:  Joanie C Neumann; Garvin L Chandler; Vanessa A Damoulis; Nicholas J Fustino; Katherine Lillard; Leendert Looijenga; Linda Margraf; Dinesh Rakheja; James F Amatruda
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-20       Impact factor: 11.205

6.  An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15.

Authors:  Liliana Fernandez; Douglas A Marchuk; Jennifer L Moran; David R Beier; Howard A Rockman
Journal:  Mamm Genome       Date:  2009-04-23       Impact factor: 2.957

7.  A forward genetic screen in mice identifies mutants with abnormal cortical patterning.

Authors:  Seungshin Ha; Rolf W Stottmann; Andrew J Furley; David R Beier
Journal:  Cereb Cortex       Date:  2013-08-22       Impact factor: 5.357

8.  ENU induced single mutation locus on chr 16 leads to high-frequency hearing loss in mice.

Authors:  Yan Jiao; Chun Cai; Mohammad Habiby Kermany; Jian Yan; Qing Cai; Darla Miller; Daniel Goldowitz; Xinmin Li; Tai-June Yoo; Weikuan Gu
Journal:  Genes Genet Syst       Date:  2009-06       Impact factor: 1.517

9.  Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results.

Authors:  Mary L Marazita; Andrew C Lidral; Jeffrey C Murray; L Leigh Field; Brion S Maher; Toby Goldstein McHenry; Margaret E Cooper; Manika Govil; Sandra Daack-Hirsch; Bridget Riley; Astanand Jugessur; Temis Felix; Lina Morene; M Adela Mansilla; Alexandre R Vieira; Kim Doheny; Elizabeth Pugh; Consuelo Valencia-Ramirez; Mauricio Arcos-Burgos
Journal:  Hum Hered       Date:  2009-06-11       Impact factor: 0.444

10.  An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions.

Authors:  Carolien Wansleeben; Léon van Gurp; Harma Feitsma; Carla Kroon; Ester Rieter; Marlies Verberne; Victor Guryev; Edwin Cuppen; Frits Meijlink
Journal:  PLoS One       Date:  2011-04-29       Impact factor: 3.240
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