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Literature DB >> 23632795

Controlling complexity: the clinical relevance of mouse complex genetics.

Klaus Schughart¹, Claude Libert, Martien J Kas.

Abstract

Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.

Entities: Species

Mesh：

Year: 2013 PMID： 23632795 PMCID： PMC3798854 DOI： 10.1038/ejhg.2013.79

Source DB: PubMed Journal: Eur J Hum Genet ISSN： 1018-4813 Impact factor: 4.246

71 in total

Review 1. Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry.

Authors: Brian P Zambrowicz; C Alexander Turner; Arthur T Sands
Journal: Curr Opin Pharmacol Date: 2003-10 Impact factor: 5.547

2. How host defense is encoded in the mammalian genome.

Authors: Bruce Beutler; Christopher C Goodnow
Journal: Mamm Genome Date: 2010-12-25 Impact factor: 2.957

3. Fusion between immunoglobulin-secreting and nonsecreting myeloma cell lines.

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Journal: Eur J Immunol Date: 1976-04 Impact factor: 5.532

4. Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome.

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Journal: Nature Date: 2005-03-31 Impact factor: 49.962

5. Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region.

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Journal: Blood Cells Mol Dis Date: 1998-09 Impact factor: 3.039

Review 6. Genetic and genomic insights into the molecular basis of atherosclerosis.

Authors: Yaoyu Chen; Jarod Rollins; Beverly Paigen; Xiaosong Wang
Journal: Cell Metab Date: 2007-09 Impact factor: 27.287

7. Diabetes-obesity syndromes in mice.

Authors: D L Coleman
Journal: Diabetes Date: 1982 Impact factor: 9.461

Review 8. ENU mutagenesis, a way forward to understand gene function.

Authors: Abraham Acevedo-Arozena; Sara Wells; Paul Potter; Michelle Kelly; Roger D Cox; Steve D M Brown
Journal: Annu Rev Genomics Hum Genet Date: 2008 Impact factor: 8.929

9. Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway.

Authors: Kazuhiro Shimomura; Phillip L Lowrey; Martha Hotz Vitaterna; Ethan D Buhr; Vivek Kumar; Peter Hanna; Chiaki Omura; Mariko Izumo; Sharon S Low; R Keith Barrett; Silvia I LaRue; Carla B Green; Joseph S Takahashi
Journal: Proc Natl Acad Sci U S A Date: 2010-04-19 Impact factor: 11.205

10. A new set of BXD recombinant inbred lines from advanced intercross populations in mice.

Authors: Jeremy L Peirce; Lu Lu; Jing Gu; Lee M Silver; Robert W Williams
Journal: BMC Genet Date: 2004-04-29 Impact factor: 2.797

12 in total

1. The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice.

Authors: S Tokuda; T Z Do Valle; L Batista; D Simon-Chazottes; L Guillemot; M Bouloy; M Flamand; X Montagutelli; J-J Panthier
Journal: Genes Immun Date: 2015-01-08 Impact factor: 2.676

2. Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research.

Authors: Teri A Manolio; Douglas M Fowler; Lea M Starita; Melissa A Haendel; Daniel G MacArthur; Leslie G Biesecker; Elizabeth Worthey; Rex L Chisholm; Eric D Green; Howard J Jacob; Howard L McLeod; Dan Roden; Laura Lyman Rodriguez; Marc S Williams; Gregory M Cooper; Nancy J Cox; Gail E Herman; Stephen Kingsmore; Cecilia Lo; Cathleen Lutz; Calum A MacRae; Robert L Nussbaum; Jose M Ordovas; Erin M Ramos; Peter N Robinson; Wendy S Rubinstein; Christine Seidman; Barbara E Stranger; Haoyi Wang; Monte Westerfield; Carol Bult
Journal: Cell Date: 2017-03-23 Impact factor: 41.582

3. Evolutionary rewiring of regulatory networks contributes to phenotypic differences between human and mouse orthologous genes.

Authors: Doyeon Ha; Donghyo Kim; Inhae Kim; Youngchul Oh; JungHo Kong; Seong Kyu Han; Sanguk Kim
Journal: Nucleic Acids Res Date: 2022-02-28 Impact factor: 16.971

Review 4. Application of Mouse Models to Research in Hearing and Balance.

Authors: Kevin K Ohlemiller; Sherri M Jones; Kenneth R Johnson
Journal: J Assoc Res Otolaryngol Date: 2016-10-17

5. Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry.

Authors: Chotima Böttcher; Stephan Schlickeiser; Marjolein A M Sneeboer; Lot D de Witte; Josef Priller; Desiree Kunkel; Anniki Knop; Evdokia Paza; Pawel Fidzinski; Larissa Kraus; Gijsje J L Snijders; René S Kahn; Axel R Schulz; Henrik E Mei; Elly M Hol; Britta Siegmund; Rainer Glauben; Eike J Spruth
Journal: Nat Neurosci Date: 2018-12-17 Impact factor: 24.884