BACKGROUND AND PURPOSE: Although stroke is strongly associated with hypertension, some individuals with normal blood pressure (BP) experience a stroke. This prospective study explored risk factors for stroke in subjects with normal BP. METHODS: A total of 11,228 men and 17,174 women, 45 to 73 years old, were examined in a population-based cohort study. Normal BP was defined as BP <140/90 mm Hg and no treatment for hypertension. The incidence of stroke was followed over a mean period of 6 years. RESULTS: In the cohort, 10,938 (38%) had normal BP. Of them, 56 patients experienced a first-ever stroke (12% of all stroke). Compared with subjects without stroke during follow-up, these stroke subjects were older, had lower education, were often smokers and alcohol nondrinkers, and had a history of coronary heart disease (CHD), gastric ulcer, or renal calculus. Subjects with stroke had a higher body mass index (BMI) and a high-normal BP (130 to 139/85 to 89 mm Hg) more often. In a backward stepwise Cox-regression analysis, age (per 1 year; relative risk [RR], 1.12), current smoking (RR, 3.21), BMI (per SD; RR, 1.39), high-normal diastolic BP (RR, 2.35), history of CHD (RR, 4.92), and gastric ulcer (RR, 2.21) remained significantly associated with incidence of stroke. CONCLUSIONS: In subjects with normal BP, there are a number of potentially modifiable risk factors associated with an increased incidence of stroke.
BACKGROUND AND PURPOSE: Although stroke is strongly associated with hypertension, some individuals with normal blood pressure (BP) experience a stroke. This prospective study explored risk factors for stroke in subjects with normal BP. METHODS: A total of 11,228 men and 17,174 women, 45 to 73 years old, were examined in a population-based cohort study. Normal BP was defined as BP <140/90 mm Hg and no treatment for hypertension. The incidence of stroke was followed over a mean period of 6 years. RESULTS: In the cohort, 10,938 (38%) had normal BP. Of them, 56 patients experienced a first-ever stroke (12% of all stroke). Compared with subjects without stroke during follow-up, these stroke subjects were older, had lower education, were often smokers and alcohol nondrinkers, and had a history of coronary heart disease (CHD), gastric ulcer, or renal calculus. Subjects with stroke had a higher body mass index (BMI) and a high-normal BP (130 to 139/85 to 89 mm Hg) more often. In a backward stepwise Cox-regression analysis, age (per 1 year; relative risk [RR], 1.12), current smoking (RR, 3.21), BMI (per SD; RR, 1.39), high-normal diastolic BP (RR, 2.35), history of CHD (RR, 4.92), and gastric ulcer (RR, 2.21) remained significantly associated with incidence of stroke. CONCLUSIONS: In subjects with normal BP, there are a number of potentially modifiable risk factors associated with an increased incidence of stroke.
Authors: Kathryn E Hitchcock; Nikolas M Ivancevich; Kevin J Haworth; Danielle N Caudell Stamper; Deborah C Vela; Jonathan T Sutton; Gail J Pyne-Geithman; Christy K Holland Journal: Ultrasound Med Biol Date: 2011-08 Impact factor: 2.998
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Authors: S Karama; S Ducharme; J Corley; F Chouinard-Decorte; J M Starr; J M Wardlaw; M E Bastin; I J Deary Journal: Mol Psychiatry Date: 2015-02-10 Impact factor: 15.992
Authors: Ellen Hanson; Staffan Nilsson; Katarina Jood; Bo Norrving; Gunnar Engström; Christian Blomstrand; Arne Lindgren; Olle Melander; Christina Jern Journal: PLoS One Date: 2013-09-25 Impact factor: 3.240