| Literature DB >> 15615520 |
Susanna Bosi1, Luigi Feruglio, Tatiana Da Ros, Giampiero Spalluto, Barbara Gregoretti, Michela Terdoslavich, Giuliana Decorti, Sabina Passamonti, Stefano Moro, Maurizio Prato.
Abstract
A series of water-soluble fullerene C(60) derivatives has been investigated for their cytotoxic and hemolytic properties, with the aim to correlate structure with toxicity. We observed that cationic chains induce significant toxicity while the presence of neutral or anionic moieties did not produce any response in our model. A validation of these experimental observations has been performed by theoretical studies in which hydrophilic and hydrophobic surface areas were correlated quantitatively with hemolytic properties.Entities:
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Year: 2004 PMID： 15615520 DOI： 10.1021/jm0497489
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446