Literature DB >> 15611883

Unraveling the mechanism of the farnesyltransferase enzyme.

Sérgio Filipe Sousa1, Pedro Alexandrino Fernandes, Maria João Ramos.   

Abstract

Farnesyltransferase enzyme (FTase) is currently one of the most fascinating targets in cancer research. Studies in other areas, namely in the fight against parasites and viruses, have also led to very promising results. However, in spite of the thrilling achievements in the development of farnesyltransferase inhibitors (FTIs) over the past few years, the farnesylation mechanism remains, to some degree, a mystery. This review tries to shed some light on this puzzling enzyme by analyzing seven key mechanistic dilemmas, based on recent studies that have dramatically changed the way this enzyme is currently perceived.

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Year:  2004        PMID： 15611883     DOI： 10.1007/s00775-004-0612-6

Source DB:  PubMed          Journal:  J Biol Inorg Chem        ISSN： 0949-8257            Impact factor:   3.358


  77 in total

Review 1.  Function and mechanism of zinc metalloenzymes.

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Journal:  J Nutr       Date:  2000-05       Impact factor: 4.798

2.  Non-thiol farnesyltransferase inhibitors: FTase-inhibition and cellular activity of benzophenone-based bisubstrate analogue farnesyltransferase inhibitors.

Authors:  Andreas Mitsch; Silke Bergemann; Ronald Gust; Isabel Sattler; Martin Schlitzer
Journal:  Arch Pharm (Weinheim)       Date:  2003-07       Impact factor: 3.751

3.  Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes.

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4.  Farnesyl protein transferase: identification of K164 alpha and Y300 beta as catalytic residues by mutagenesis and kinetic studies.

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Journal:  Biochemistry       Date:  1999-08-31       Impact factor: 3.162

Review 5.  Protein prenylation: molecular mechanisms and functional consequences.

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Journal:  Annu Rev Biochem       Date:  1996       Impact factor: 23.643

6.  Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release.

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Journal:  Biochemistry       Date:  1995-05-23       Impact factor: 3.162

7.  All ras proteins are polyisoprenylated but only some are palmitoylated.

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Journal:  Cell       Date:  1989-06-30       Impact factor: 41.582

8.  H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate.

Authors:  K E Hightower; C C Huang; P J Casey; C A Fierke
Journal:  Biochemistry       Date:  1998-11-03       Impact factor: 3.162

9.  Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium.

Authors:  Heather L Hartman; Katherine E Bowers; Carol A Fierke
Journal:  J Biol Chem       Date:  2004-05-05       Impact factor: 5.157

Review 10.  ras and human tumors.

Authors:  S Rodenhuis
Journal:  Semin Cancer Biol       Date:  1992-08       Impact factor: 15.707
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  9 in total

1.  Metals in proteins: cluster analysis studies.

Authors:  Juan A C Tamames; Maria João Ramos
Journal:  J Mol Model       Date:  2010-05-21       Impact factor: 1.810

2.  Molecular dynamics analysis of a series of 22 potential farnesyltransferase substrates containing a CaaX-motif.

Authors:  Sérgio F Sousa; João T S Coimbra; Diogo Paramos; Rita Pinto; Rodrigo S Guimarães; Vitor Teixeira; Pedro A Fernandes; Maria J Ramos
Journal:  J Mol Model       Date:  2012-09-26       Impact factor: 1.810

3.  Computational studies of the farnesyltransferase ternary complex part I: substrate binding.

Authors:  Guanglei Cui; Bing Wang; Kenneth M Merz
Journal:  Biochemistry       Date:  2005-12-20       Impact factor: 3.162

4.  Driven to death: Inhibition of farnesylation increases Ras activity and promotes growth arrest and cell death [corrected].

Authors:  Mandy Geryk-Hall; Yanwen Yang; Dennis P M Hughes
Journal:  Mol Cancer Ther       Date:  2010-04-20       Impact factor: 6.261

5.  Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase.

Authors:  Thangaiah Subramanian; June E Pais; Suxia Liu; Jerry M Troutman; Yuta Suzuki; Karunai Leela Subramanian; Carol A Fierke; Douglas A Andres; H Peter Spielmann
Journal:  Biochemistry       Date:  2012-10-02       Impact factor: 3.162

6.  The correlation of 113Cd NMR and 111mCd PAC spectroscopies provides a powerful approach for the characterization of the structure of Cd(II)-substituted Zn(II) proteins.

Authors:  Olga Iranzo; Tamas Jakusch; Kyung-Hoon Lee; Lars Hemmingsen; Vincent L Pecoraro
Journal:  Chemistry       Date:  2009       Impact factor: 5.236

7.  Caged protein prenyltransferase substrates: tools for understanding protein prenylation.

Authors:  Amanda J DeGraw; Michael A Hast; Juhua Xu; Daniel Mullen; Lorena S Beese; George Barany; Mark D Distefano
Journal:  Chem Biol Drug Des       Date:  2008-09       Impact factor: 2.817

8.  Theoretical Studies on Catalysis Mechanisms of Serum Paraoxonase 1 and Phosphotriesterase Diisopropyl Fluorophosphatase Suggest the Alteration of Substrate Preference from Paraoxonase to DFP.

Authors:  Hao Zhang; Ling Yang; Ying-Ying Ma; Chaoyuan Zhu; Shenghsien Lin; Rong-Zhen Liao
Journal:  Molecules       Date:  2018-07-07       Impact factor: 4.411

Review 9.  Zinc-binding cysteines: diverse functions and structural motifs.

Authors:  Nicholas J Pace; Eranthie Weerapana
Journal:  Biomolecules       Date:  2014-04-17
  9 in total

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