Literature DB >> 15610767

Modelling the disposable soma theory of ageing.

Fotios Drenos1, Thomas B L Kirkwood.   

Abstract

We describe a mathematical model, developed using the Mathematica programming system of the disposable soma theory of ageing. The model makes explicit predictions about the optimal strategies for investment in somatic maintenance versus investments in growth and reproduction and confirms the central prediction of the disposable soma theory that the optimum investment in somatic maintenance is less than what would be required for indefinite longevity. We also describe how the optimal investment in maintenance is affected by varying the parameters that specify the schedules of reproduction and mortality.

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Year:  2005        PMID: 15610767     DOI: 10.1016/j.mad.2004.09.026

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN: 0047-6374            Impact factor:   5.432


  17 in total

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2.  Cranberry interacts with dietary macronutrients to promote healthy aging in Drosophila.

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Review 3.  Very small embryonic-like stem cells in adult tissues-potential implications for aging.

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Journal:  Antioxid Redox Signal       Date:  2017-10-17       Impact factor: 8.401

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6.  Dietary deprivation extends lifespan in Caenorhabditis elegans.

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7.  Cell resilience in species life spans: a link to inflammation?

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8.  Reproductive Status Modulates Mortality Rate, Lifespan and Egg Production, but Do Not the Physiological Aging in the Field Cricket Gryllus assimilis (Fabricius, 1775) (Orthoptera: Gryllidae).

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Review 9.  Metabolic and neuropsychiatric effects of calorie restriction and sirtuins.

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Journal:  Annu Rev Physiol       Date:  2012-10-01       Impact factor: 19.318

10.  Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila.

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