Literature DB >> 15609976

A new polymer-supported reagent for the synthesis of beta-lactams in solution.

Donato Donati1, Costanza Morelli, Andrea Porcheddu, Maurizio Taddei.   

Abstract

A modified Mukaiyama reagent was prepared on a PS-DVB resin. This reagent was used for the preparation of beta-lactams, using the Staudinger reaction. The products were obtained by generating the ketene from a carboxylic acid under sonication with the resin followed by reaction with the imine. Excess of the imine was removed by reduction followed by acid scavenging.

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Year:  2004        PMID: 15609976     DOI: 10.1021/jo048400i

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  2 in total

1.  A simple and rapid protocol for the synthesis of phenacyl derivatives using macroporous polymer-supported reagents.

Authors:  Ali R Kiasat; Soheil Sayyahi
Journal:  Mol Divers       Date:  2009-09-11       Impact factor: 2.943

2.  Microwave-assisted esterification of N-acetyl-L-phenylalanine using modified Mukaiyama's reagents: A new approach involving ionic liquids.

Authors:  Hua Zhao; Zhiyan Song; Janet V Cowins; Olarongbe Olubajo
Journal:  Int J Mol Sci       Date:  2008-01-16       Impact factor: 6.208

  2 in total

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