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Literature DB >> 1560546

Cytolytic T lymphocytes specific for tumors and infected cells from mice with a retrovirus-induced immunodeficiency syndrome.

J G Erbe¹, K A Green, K M Crassi, H C Morse, W R Green.

Abstract

LP-BM5 retrovirus complex-infected C57BL/6 mice develop immunodeficiency, somewhat analogous to AIDS, termed murine AIDS (MAIDS). After secondary stimulation with syngeneic B-cell lymphomas from LP-BM5-infected mice, C57BL/6 mice produced vigorous CD8+ cytotoxic T lymphocytes specific for MAIDS-associated tumors. An anti-LP-BM5 specificity was suggested because spleen and lymph node cells from LP-BM5-infected mice served as target cells in competition assays, and cells from LP-BM5, but not ecotropic, virus-infected mice functioned as secondary in vitro stimulators to generate cytotoxic T lymphocytes to MAIDS tumors.

Entities: CellLine Disease Species

Mesh：

Substances：
CD8 Antigens

Year: 1992 PMID： 1560546 PMCID： PMC241097

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

34 in total

1. Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice.

Authors: S K Chattopadhyay; D N Sengupta; T N Fredrickson; H C Morse; J W Hartley
Journal: J Virol Date: 1991-08 Impact factor: 5.103

2. Topological mapping of murine leukemia virus proteins by competition-binding assays with monoclonal antibodies.

Authors: M R Stone; R C Nowinski
Journal: Virology Date: 1980-01-30 Impact factor: 3.616

3. Characteristics of the cell populations involved in extra-thymic lymphosarcoma induced in C57BL/6 mice by RadLV-Rs.

Authors: E Legrand; R Daculsi; J F Duplan
Journal: Leuk Res Date: 1981 Impact factor: 3.156

4. A selective signaling defect in helper T cells induced by antigen-presenting cells from mice with murine acquired immunodeficiency syndrome.

Authors: T Mizuochi; J Mizuguchi; T Uchida; K Ohnishi; M Nakanishi; Y Asano; T Kakiuchi; Y Fukushima; K Okuyama; H C Morse
Journal: J Immunol Date: 1990-01-01 Impact factor: 5.422

5. H-2-associated and background genes influence the development of a murine retrovirus-induced immunodeficiency syndrome.

Authors: M Makino; H C Morse; T N Fredrickson; J W Hartley
Journal: J Immunol Date: 1990-06-01 Impact factor: 5.422

1. Immunotherapy of murine retrovirus-induced acquired immunodeficiency by CD4 T regulatory cell depletion and PD-1 blockade.

Authors: Wen Li; William R Green
Journal: J Virol Date: 2011-09-14 Impact factor: 5.103

2. Adoptive transfer of polyclonal and cloned cytolytic T lymphocytes (CTL) specific for mouse AIDS-associated tumors is effective in preserving CTL responses: a measure of protection against LP-BM5 retrovirus-induced immunodeficiency.

Authors: W R Green; K A Green; K M Crassi
Journal: J Virol Date: 1994-07 Impact factor: 5.103

3. Dissociation between lymphoproliferative responses and virus replication in mice with different sensitivities to retrovirus-induced immunodeficiency.

Authors: J M Pozsgay; S Reid; P M Pitha
Journal: J Virol Date: 1993-02 Impact factor: 5.103

3 in total

Cytolytic T lymphocytes specific for tumors and infected cells from mice with a retrovirus-induced immunodeficiency syndrome.

1. Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice.

2. Topological mapping of murine leukemia virus proteins by competition-binding assays with monoclonal antibodies.

3. Characteristics of the cell populations involved in extra-thymic lymphosarcoma induced in C57BL/6 mice by RadLV-Rs.

4. A selective signaling defect in helper T cells induced by antigen-presenting cells from mice with murine acquired immunodeficiency syndrome.

5. H-2-associated and background genes influence the development of a murine retrovirus-induced immunodeficiency syndrome.

6. Expression of defective virus and cytokine genes in murine AIDS.

7. A virus-encoded "superantigen" in a retrovirus-induced immunodeficiency syndrome of mice.

8. HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals.

9. Immunodeficiency and clonal growth of target cells induced by helper-free defective retrovirus.

10. Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS).

1. Immunotherapy of murine retrovirus-induced acquired immunodeficiency by CD4 T regulatory cell depletion and PD-1 blockade.

2. Adoptive transfer of polyclonal and cloned cytolytic T lymphocytes (CTL) specific for mouse AIDS-associated tumors is effective in preserving CTL responses: a measure of protection against LP-BM5 retrovirus-induced immunodeficiency.

3. Dissociation between lymphoproliferative responses and virus replication in mice with different sensitivities to retrovirus-induced immunodeficiency.