| Literature DB >> 15603957 |
Stephen J Lewis1, Adrian L Smith, Joseph G Neduvelil, Graeme I Stevenson, Matthew J Lindon, A Brian Jones, Mark S Shearman, Dirk Beher, Earl Clarke, Jonathan D Best, James E Peachey, Timothy Harrison, J Luis Castro.
Abstract
A new series of gamma-secretase inhibitors was developed from an in-house screening hit based on a benzobicyclo[4.2.1]nonane core. Lead optimisation studies led to the development of a series of potent inhibitors and in vivo efficacy was demonstrated.Entities:
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Year: 2005 PMID： 15603957 DOI： 10.1016/j.bmcl.2004.10.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823