Literature DB >> 33603966

Investigation on the Anticancer Activity of Symmetric and Unsymmetric Cyclic Sulfamides.

Jaden Jungho Jun1,2, Divya Duscharla3, Ramesh Ummanni3, Paul R Hanson2, Sanjay V Malhotra4,5.   

Abstract

The sulfamide functional group has been extensively employed in organic synthesis to discover probes and drugs in various applications such as cancer, human immunodeficiency virus (HIV), virus, and diabetes. Herein, we describe the synthesis of 7-membered symmetric and unsymmetric sulfamide compounds and their biological evaluation through the National Cancer Institute (NCI) panel of 60 human tumor cell lines (NCI-60) and the mechanism of action study. The results of a study from the NCI-60 cell line exhibited that many synthesized cyclic sulfamide compounds inhibited breast cancer (MDA-MB-468). The mechanism of action study of a representative compound 18 showed the inhibition of proliferation and apoptosis in A549 lung cancer cells.
© 2021 American Chemical Society.

Entities:  

Year:  2021        PMID： 33603966      PMCID： PMC7883376          DOI： 10.1021/acsmedchemlett.0c00460

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  30 in total

1.  The therapeutic potential of small molecule TACE inhibitors.

Authors:  F C Nelson; A Zask
Journal:  Expert Opin Investig Drugs       Date:  1999-04       Impact factor: 6.206

2.  Effect of structural stress on the flexibility and adaptability of HIV-1 protease.

Authors:  Daniel P Oehme; David J D Wilson; Robert T C Brownlee
Journal:  J Chem Inf Model       Date:  2011-04-18       Impact factor: 4.956

Review 3.  Development of human tumor cell line panels for use in disease-oriented drug screening.

Authors:  R H Shoemaker; A Monks; M C Alley; D A Scudiero; D L Fine; T L McLemore; B J Abbott; K D Paull; J G Mayo; M R Boyd
Journal:  Prog Clin Biol Res       Date:  1988

4.  Metallacarborane Sulfamides: Unconventional, Specific, and Highly Selective Inhibitors of Carbonic Anhydrase IX.

Authors:  Bohumír Grüner; Jiří Brynda; Viswanath Das; Václav Šícha; Jana Štěpánková; Jan Nekvinda; Josef Holub; Klára Pospíšilová; Milan Fábry; Petr Pachl; Vlastimil Král; Michael Kugler; Vlastimil Mašek; Martina Medvedíková; Stanislava Matějková; Alice Nová; Barbora Lišková; Soňa Gurská; Petr Džubák; Marián Hajdúch; Pavlína Řezáčová
Journal:  J Med Chem       Date:  2019-10-16       Impact factor: 7.446

5.  Synthesis, anti-cancer screening and tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibition activity of novel piperidinyl sulfamides.

Authors:  Jung Ho Jun; Vineet Kumar; Thomas S Dexheimer; Iwona Wedlich; Marc C Nicklaus; Yves Pommier; Sanjay V Malhotra
Journal:  Eur J Pharm Sci       Date:  2017-10-13       Impact factor: 4.384

6.  The sulfamide motif in the design of enzyme inhibitors.

Authors:  Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Journal:  Expert Opin Ther Pat       Date:  2006-01       Impact factor: 6.674

7.  Cyclic sulfamide gamma-secretase inhibitors.

Authors:  Tim Sparey; Dirk Beher; Jonathan Best; Mirlinda Biba; José L Castro; Earl Clarke; Joanne Hannam; Timothy Harrison; Huw Lewis; Andrew Madin; Mark Shearman; Bindi Sohal; Nancy Tsou; Christopher Welch; Jonathan Wrigley
Journal:  Bioorg Med Chem Lett       Date:  2005-10-01       Impact factor: 2.823

8.  Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities.

Authors:  J Hultén; N M Bonham; U Nillroth; T Hansson; G Zuccarello; A Bouzide; J Aqvist; B Classon; U H Danielson; A Karlén; I Kvarnström; B Samuelsson; A Hallberg
Journal:  J Med Chem       Date:  1997-03-14       Impact factor: 7.446

9.  The synthesis of novel sulfamides derived from β-benzylphenethylamines as acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase enzymes inhibitors.

Authors:  Akın Akıncıoğlu; Ebutalib Kocaman; Hülya Akıncıoğlu; Ramin Ekhteiari Salmas; Serdar Durdagi; İlhami Gülçin; Claudiu T Supuran; Süleyman Göksu
Journal:  Bioorg Chem       Date:  2017-08-23       Impact factor: 5.275

10.  Sulfamide derivatives as transition state analogue inhibitors for carboxypeptidase A.

Authors:  Jung Dae Park; Dong H Kim
Journal:  Bioorg Med Chem       Date:  2004-05-01       Impact factor: 3.641
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  1 in total

1.  1,2,3-Triazole Tethered Hybrid Capsaicinoids as Antiproliferative Agents Active against Lung Cancer Cells (A549).

Authors:  Arif Khan; Fatima Naaz; Rafia Basit; Deepak Das; Piyush Bisht; Majeed Shaikh; Bilal Ahmad Lone; Yuba Raj Pokharel; Qazi Naveed Ahmed; Shazia Parveen; Intzar Ali; Shashank Kumar Singh; Gousia Chashoo; Syed Shafi
Journal:  ACS Omega       Date:  2022-09-01
  1 in total

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