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Literature DB >> 15601769

Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy.

Janine Mauzeroll¹, Allen J Bard, Omeed Owhadian, Terrence J Monks.

Abstract

The cytotoxicity of menadione on hepatocytes was studied by using the substrate generation/tip collection mode of scanning electrochemical microscopy by exposing the cells to menadione and detecting the menadione-S-glutathione conjugate (thiodione) that is formed during the cellular detoxication process and is exported from the cell by an ATP-dependent pump. This efflux was electrochemically detected and allowed scanning electrochemical microscopy monitoring and imaging of single cells and groups of highly confluent live cells. Based on a constant flux model, approximately 6 x 10(6) molecules of thiodione per cell per second are exported from monolayer cultures of Hep G2 cells.

Entities: Chemical Disease Gene

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Year: 2004 PMID： 15601769 PMCID： PMC539751 DOI： 10.1073/pnas.0407613101

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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