Literature DB >> 15600436

Solvable biological evolution models with general fitness functions and multiple mutations in parallel mutation-selection scheme.

David B Saakian1, Chin-Kun Hu, H Khachatryan.   

Abstract

In a recent paper [Phys. Rev. E 69, 046121 (2004)]], we used the Suzuki-Trottere formalism to study a quasispecies biological evolution model in a parallel mutation-selection scheme with a single-peak fitness function and a point mutation. In the present paper, we extend such a study to evolution models with more general fitness functions or multiple mutations in the parallel mutation-selection scheme. We give some analytical equations to define the error thresholds for some general cases of mean-field-like or symmetric mutation schemes and fitness functions. We derive some equations for the dynamics in the case of a point mutation and polynomial fitness functions. We derive exact dynamics for two-point mutations, asymmetric mutations, and the four-value spin model with a single-peak fitness function. The same method is applied for the model with a royal road fitness function. We derive the steady-state distribution for the single-peak fitness function.

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Year:  2004        PMID: 15600436     DOI: 10.1103/PhysRevE.70.041908

Source DB:  PubMed          Journal:  Phys Rev E Stat Nonlin Soft Matter Phys        ISSN: 1539-3755


  6 in total

1.  Quasispecies theory for multiple-peak fitness landscapes.

Authors:  David B Saakian; E Muñoz; Chin-Kun Hu; M W Deem
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2006-04-11

2.  Exact solution of the Eigen model with general fitness functions and degradation rates.

Authors:  David B Saakian; Chin-Kun Hu
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-20       Impact factor: 11.205

3.  Quasispecies theory for horizontal gene transfer and recombination.

Authors:  Enrique Muñoz; Jeong-Man Park; Michael W Deem
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2008-12-23

4.  Lethal mutants and truncated selection together solve a paradox of the origin of life.

Authors:  David B Saakian; Christof K Biebricher; Chin-Kun Hu
Journal:  PLoS One       Date:  2011-07-26       Impact factor: 3.240

5.  Thermodynamic basis for the emergence of genomes during prebiotic evolution.

Authors:  Hyung-June Woo; Ravi Vijaya Satya; Jaques Reifman
Journal:  PLoS Comput Biol       Date:  2012-05-31       Impact factor: 4.475

6.  The rich phase structure of a mutator model.

Authors:  David B Saakian; Tatiana Yakushkina; Chin-Kun Hu
Journal:  Sci Rep       Date:  2016-10-10       Impact factor: 4.379

  6 in total

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