PURPOSE: To establish the reproducibility of a standardized region of interest (ROI) drawing procedure in delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC). MATERIAL AND METHODS: A large ROI in lateral and medial femoral weight-bearing cartilage was drawn in images of 12 healthy male volunteers by 6 investigators with different skills in MRI. The procedure was done twice, with a 1-week interval. Calculated T1-values were evaluated for intra- and interobserver variability. RESULTS: The mean interobserver variability for both compartments ranged between 1.3% and 2.3% for the 6 different investigators without correlation to their experience in MRI. Post-contrast intra-observer variability was low in both the lateral and the medial femoral cartilage, 2.6% and 1.5%, respectively. The larger variability in lateral than in medial cartilage was related to slightly longer and thinner ROIs. CONCLUSION: Intra-observer variability and interobserver variability are both low when a large standardized ROI is used in dGEMRIC. The experience of the investigator does not affect the variability, which further supports a clinical applicability of the method.
PURPOSE: To establish the reproducibility of a standardized region of interest (ROI) drawing procedure in delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC). MATERIAL AND METHODS: A large ROI in lateral and medial femoral weight-bearing cartilage was drawn in images of 12 healthy male volunteers by 6 investigators with different skills in MRI. The procedure was done twice, with a 1-week interval. Calculated T1-values were evaluated for intra- and interobserver variability. RESULTS: The mean interobserver variability for both compartments ranged between 1.3% and 2.3% for the 6 different investigators without correlation to their experience in MRI. Post-contrast intra-observer variability was low in both the lateral and the medial femoral cartilage, 2.6% and 1.5%, respectively. The larger variability in lateral than in medial cartilage was related to slightly longer and thinner ROIs. CONCLUSION: Intra-observer variability and interobserver variability are both low when a large standardized ROI is used in dGEMRIC. The experience of the investigator does not affect the variability, which further supports a clinical applicability of the method.
Authors: Simon Macmull; Parag K Jaiswal; George Bentley; John A Skinner; Richard W J Carrington; Tim W R Briggs Journal: Int Orthop Date: 2012-01-14 Impact factor: 3.075
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Authors: Rianne A van der Heijden; Bas A de Vries; Dirk H J Poot; Marienke van Middelkoop; Sita M A Bierma-Zeinstra; Gabriel P Krestin; Edwin H G Oei Journal: Quant Imaging Med Surg Date: 2021-01
Authors: Jasper van Tiel; Max Reijman; Pieter K Bos; Job Hermans; Gerben M van Buul; Esther E Bron; Stefan Klein; Jan A N Verhaar; Gabriel P Krestin; Sita M A Bierma-Zeinstra; Harrie Weinans; Gyula Kotek; Edwin H G Oei Journal: PLoS One Date: 2013-11-06 Impact factor: 3.240