Literature DB >> 15583871

Mitochondrial permeability transition triggers the release of mtDNA fragments.

M Patrushev1, V Kasymov, V Patrusheva, T Ushakova, V Gogvadze, A Gaziev.   

Abstract

Fragments of mitochondrial DNA are released from mitochondria upon opening of the mitochondrial permeability transition pore. Cyclosporin A, an inhibitor of pore opening, completely prevented the release of mitochondrial fragments. Induction of mitochondrial permeability transition and subsequent release of the fragments of mitochondrial DNA could be one cause of genomic instability in the cell.

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Year:  2004        PMID： 15583871     DOI： 10.1007/s00018-004-4424-1

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  34 in total

Review 1.  [Postconditioning: a brief review].

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Review 2.  PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond.

Authors:  B M Marte; J Downward
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Journal:  Mol Neurobiol       Date:  2015-02-17       Impact factor: 5.590

4.  Heme oxygenase-1 induction protects the heart and modulates cellular and extracellular remodelling after myocardial infarction in rats.

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5.  [Complication of a complex heart failure: perforation of a sinus Valsalva [corrected] aneurysm].

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7.  Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion.

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Review 8.  Anti-inflammatory actions of the heme oxygenase-1 pathway.

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9.  [Protective effects of a delta-opioid-receptor agonist and an oxygen radical scavenger on postischemic hearts].

Authors:  Jochen D Schipke; Frank Nickel; Emmeran Gams; Ulrich Sunderdiek
Journal:  Herz       Date:  2004-05       Impact factor: 1.443

10.  Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway.

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  48 in total

1.  Alteration of mtDNA copy number, mitochondrial gene expression and extracellular DNA content in mice after irradiation at lethal dose.

Authors:  Edward V Evdokimovsky; Tatjana E Ushakova; Andrej A Kudriavtcev; Ajub I Gaziev
Journal:  Radiat Environ Biophys       Date:  2010-09-03       Impact factor: 1.925

Review 2.  Mitophagy Contributes to the Pathogenesis of Inflammatory Diseases.

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Review 3.  Mitochondrial fidelity and metabolic agility control immune cell fate and function.

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4.  The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases.

Authors:  Kiichi Nakahira; Shu Hisata; Augustine M K Choi
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5.  VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease.

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Journal:  Science       Date:  2019-12-19       Impact factor: 47.728

Review 6.  Safeguarding mitochondrial genomes in higher eukaryotes.

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Review 7.  Mitochondrial DNA in Sepsis.

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9.  Cell free mitochondrial DNA in serum and milk associated with bovine mastitis: a pilot study.

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Review 10.  NLRP3 inflammasomes are involved in the progression of postoperative cognitive dysfunction: from mechanism to treatment.

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