Literature DB >> 9301337

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond.

B M Marte1, J Downward.   

Abstract

PKB/Akt is a serine/threonine kinase that contains a pleckstrin-homology (PH) domain and is activated in response to growth-factor treatment of cells by a mechanism involving phosphoinositide 3-OH kinase. PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, perhaps explaining its discovery as a retroviral oncogene and its amplification in many human tumours.

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Year:  1997        PMID： 9301337     DOI： 10.1016/s0968-0004(97)01097-9

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  155 in total

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2.  The midblastula transition in Xenopus embryos activates multiple pathways to prevent apoptosis in response to DNA damage.

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3.  Enteropathogenic Escherichia coli mediates antiphagocytosis through the inhibition of PI 3-kinase-dependent pathways.

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4.  Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria.

Authors:  S G Kennedy; E S Kandel; T K Cross; N Hay
Journal:  Mol Cell Biol       Date:  1999-08       Impact factor: 4.272

Review 5.  Postmitochondrial regulation of apoptosis during heart failure.

Authors:  J C Reed; G Paternostro
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

6.  Suppression of Ras-induced apoptosis by the Rac GTPase.

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7.  Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis.

Authors:  T H Holmström; S E Tran; V L Johnson; N G Ahn; S C Chow; J E Eriksson
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8.  The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal.

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9.  Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines.

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10.  Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein.

Authors:  I Gout; G Middleton; J Adu; N N Ninkina; L B Drobot; V Filonenko; G Matsuka; A M Davies; M Waterfield; V L Buchman
Journal:  EMBO J       Date:  2000-08-01       Impact factor: 11.598
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