Literature DB >> 15582432

Cytotoxic neolignans: an SAR study.

Zwe-Ling Kong1, Shin-Cheng Tzeng, Yeuk-Chuen Liu.   

Abstract

The neolignans, magnolol 1 and honokiol 2 have been reported to inhibit the growth of several tumor cell lines in vitro and in vivo. The chemical structure of magnolol and honokiol consists of biphenyl skeleton with phenolic and allylic functionalities. Analogs of 1 and 2 containing different substitution have been studies for their effect on the growth of Hep-G2 and their structure-activity relationships were reported in this work.

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Year:  2005        PMID： 15582432     DOI： 10.1016/j.bmcl.2004.10.011

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  In vitro growth inhibition of human cancer cells by novel honokiol analogs.

Authors:  Jyh Ming Lin; A S Prakasha Gowda; Arun K Sharma; Shantu Amin
Journal:  Bioorg Med Chem       Date:  2012-04-03       Impact factor: 3.641

2.  Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.

Authors:  Franck Amblard; Baskaran Govindarajan; Benjamin Lefkove; Kimberly L Rapp; Mervi Detorio; Jack L Arbiser; Raymond F Schinazi
Journal:  Bioorg Med Chem Lett       Date:  2007-06-10       Impact factor: 2.823

Review 3.  Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents.

Authors:  Mélanie Poivre; Pierre Duez
Journal:  J Zhejiang Univ Sci B       Date:  2017 Mar.       Impact factor: 3.066

4.  New acyclic bis phenylpropanoid and neolignans, from Myristica fragrans Houtt., exhibiting PARP-1 and NF-κB inhibitory effects.

Authors:  Ulyana Muñoz Acuña; Peter J Blanco Carcache; Susan Matthew; Esperanza J Carcache de Blanco
Journal:  Food Chem       Date:  2016-01-15       Impact factor: 7.514

5.  Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55.

Authors:  Viktor Rempel; Alexander Fuchs; Sonja Hinz; Tadeusz Karcz; Matthias Lehr; Uwe Koetter; Christa E Müller
Journal:  ACS Med Chem Lett       Date:  2012-11-14       Impact factor: 4.345

Review 6.  Honokiol: a novel natural agent for cancer prevention and therapy.

Authors:  S Arora; S Singh; G A Piazza; C M Contreras; J Panyam; A P Singh
Journal:  Curr Mol Med       Date:  2012-12       Impact factor: 2.222

Review 7.  Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis.

Authors:  Ding Lin; Senze Jiang; Ailian Zhang; Tong Wu; Yongchang Qian; Qingsong Shao
Journal:  Nat Prod Bioprospect       Date:  2022-03-07

8.  Semi-synthesis, structural modification and biological evaluation of 5-arylbenzofuran neolignans.

Authors:  Ding Lin; Long Wang; Zhongzhong Yan; Jiao Ye; Aixi Hu; Hongdong Liao; Juan Liu; Junmei Peng
Journal:  RSC Adv       Date:  2018-10-05       Impact factor: 3.361

9.  Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligands.

Authors:  Lukas Rycek; Roshan Puthenkalam; Michael Schnürch; Margot Ernst; Marko D Mihovilovic
Journal:  Bioorg Med Chem Lett       Date:  2014-11-04       Impact factor: 2.940

10.  Synthesis of tetrahydrohonokiol derivates and their evaluation for cytotoxic activity against CCRF-CEM leukemia, U251 glioblastoma and HCT-116 colon cancer cells.

Authors:  Marketa Bernaskova; Nadine Kretschmer; Wolfgang Schuehly; Antje Huefner; Robert Weis; Rudolf Bauer
Journal:  Molecules       Date:  2014-01-20       Impact factor: 4.411
  10 in total

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