| Literature DB >> 15582398 |
Jeyanthy Eswaran1, Eva Koronakis, Matthew K Higgins, Colin Hughes, Vassilis Koronakis.
Abstract
Bacterial multidrug resistance is a serious clinical problem and is commonly conferred by tripartite efflux 'pumps' in the prokaryotic cell envelope. Crystal structures of the three components of a drug efflux pump have now been solved: the outer membrane TolC exit duct in the year 2000, the inner membrane AcrB antiporter in 2002 and the periplasmic adaptor MexA in 2004. These structures have enhanced our understanding of the principles underlying pump assembly and operation, and present pumps as new drug targets.Mesh：
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Year: 2004 PMID： 15582398 DOI： 10.1016/j.sbi.2004.10.003
Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809