Literature DB >> 15578092

TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice.

Reiko Horai1, Akiko Nakajima, Katsuyoshi Habiro, Motoko Kotani, Susumu Nakae, Taizo Matsuki, Aya Nambu, Shinobu Saijo, Hayato Kotaki, Katsuko Sudo, Akihiko Okahara, Hidetoshi Tanioka, Toshimi Ikuse, Naoto Ishii, Pamela L Schwartzberg, Ryo Abe, Yoichiro Iwakura.   

Abstract

IL-1 receptor antagonist-deficient (IL-1Ra(-/-)) mice spontaneously develop autoimmune arthritis. We demonstrate here that T cells are required for the induction of arthritis; T cell-deficient IL-1Ra(-/-) mice did not develop arthritis, and transfer of IL-1Ra(-/-) T cells induced arthritis in nu/nu mice. Development of arthritis was also markedly suppressed by TNF-alpha deficiency. We found that TNF-alpha induced OX40 expression on T cells and blocking the interaction between either CD40 and its ligand or OX40 and its ligand suppressed development of arthritis. These findings suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40.

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Year:  2004        PMID： 15578092      PMCID： PMC529278          DOI： 10.1172/JCI20742

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  27 in total

Review 1.  On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.

Authors:  G Kollias; E Douni; G Kassiotis; D Kontoyiannis
Journal:  Immunol Rev       Date:  1999-06       Impact factor: 12.988

2.  Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process.

Authors:  C Mauri; L T Mars; M Londei
Journal:  Nat Med       Date:  2000-06       Impact factor: 53.440

Review 3.  CD40-CD40 ligand.

Authors:  C van Kooten; J Banchereau
Journal:  J Leukoc Biol       Date:  2000-01       Impact factor: 4.962

4.  Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.

Authors:  D Kontoyiannis; M Pasparakis; T T Pizarro; F Cominelli; G Kollias
Journal:  Immunity       Date:  1999-03       Impact factor: 31.745

5.  An aggressive form of polyarticular arthritis in a man with CD154 mutation (X-linked hyper-IgM syndrome).

Authors:  E A Webster; A Y Khakoo; W J Mackus; M Karpusas; D W Thomas; A Davidson; C L Christian; S Lederman
Journal:  Arthritis Rheum       Date:  1999-06

Review 6.  Antibodies to OX-40 (CD134) can identify and eliminate autoreactive T cells: implications for human autoimmune disease.

Authors:  A D Weinberg
Journal:  Mol Med Today       Date:  1998-02

7.  IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation.

Authors:  L A Joosten; M M Helsen; T Saxne; F A van De Loo; D Heinegard; W B van Den Berg
Journal:  J Immunol       Date:  1999-11-01       Impact factor: 5.422

8.  Microbial lipopeptides induce the production of IL-17 in Th cells.

Authors:  C Infante-Duarte; H F Horton; M C Byrne; T Kamradt
Journal:  J Immunol       Date:  2000-12-01       Impact factor: 5.422

9.  Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion.

Authors:  R Horai; M Asano; K Sudo; H Kanuka; M Suzuki; M Nishihara; M Takahashi; Y Iwakura
Journal:  J Exp Med       Date:  1998-05-04       Impact factor: 14.307

10.  Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice.

Authors:  R Horai; S Saijo; H Tanioka; S Nakae; K Sudo; A Okahara; T Ikuse; M Asano; Y Iwakura
Journal:  J Exp Med       Date:  2000-01-17       Impact factor: 14.307
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  39 in total

1.  Roles of interleukin-17 in an experimental Legionella pneumophila pneumonia model.

Authors:  Yoshifumi Kimizuka; Soichiro Kimura; Tomoo Saga; Makoto Ishii; Naoki Hasegawa; Tomoko Betsuyaku; Yoichiro Iwakura; Kazuhiro Tateda; Keizo Yamaguchi
Journal:  Infect Immun       Date:  2011-12-05       Impact factor: 3.441

2.  Autoinflammation and autoimmunity in systemic juvenile idiopathic arthritis.

Authors:  Peter A Nigrovic
Journal:  Proc Natl Acad Sci U S A       Date:  2015-12-17       Impact factor: 11.205

3.  A therapeutic OX40 agonist dynamically alters dendritic, endothelial, and T cell subsets within the established tumor microenvironment.

Authors:  Angela D Pardee; Dustin McCurry; Sean Alber; Peisheng Hu; Alan L Epstein; Walter J Storkus
Journal:  Cancer Res       Date:  2010-11-02       Impact factor: 12.701

4.  Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells.

Authors:  Jingsong Wang; John W Fathman; Geanncarlo Lugo-Villarino; Lucila Scimone; Ulrich von Andrian; David M Dorfman; Laurie H Glimcher
Journal:  J Clin Invest       Date:  2006-01-12       Impact factor: 14.808

Review 5.  Toll-like receptors and chronic inflammation in rheumatic diseases: new developments.

Authors:  Leo A B Joosten; Shahla Abdollahi-Roodsaz; Charles A Dinarello; Luke O'Neill; Mihai G Netea
Journal:  Nat Rev Rheumatol       Date:  2016-05-12       Impact factor: 20.543

6.  Interleukin 1 receptor antagonist deficiency presenting as infantile pustulosis mimicking infantile pustular psoriasis.

Authors:  Kira Minkis; Ivona Aksentijevich; Raphaela Goldbach-Mansky; Cynthia Magro; Rachelle Scott; Jessica G Davis; Niti Sardana; Ronit Herzog
Journal:  Arch Dermatol       Date:  2012-06

Review 7.  Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases.

Authors:  Michael Croft; Richard M Siegel
Journal:  Nat Rev Rheumatol       Date:  2017-03-09       Impact factor: 20.543

Review 8.  Th17 cytokines and arthritis.

Authors:  Erik Lubberts
Journal:  Semin Immunopathol       Date:  2010-02-04       Impact factor: 9.623

Review 9.  The role of OX40-mediated co-stimulation in T-cell activation and survival.

Authors:  William L Redmond; Carl E Ruby; Andrew D Weinberg
Journal:  Crit Rev Immunol       Date:  2009       Impact factor: 2.214

Review 10.  Lessons from animal models of arthritis over the past decade.

Authors:  Wim B van den Berg
Journal:  Arthritis Res Ther       Date:  2009-10-14       Impact factor: 5.156
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