| Literature DB >> 15577255 |
Fumiyuki Kiuchi1, Kenji Matsuo, Michiho Ito, Tran Kim Qui, Gisho Honda.
Abstract
Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 microM (1), 1.7 microM (2) and 1.7 microM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 microM).Entities:
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Year: 2004 PMID： 15577255 DOI： 10.1248/cpb.52.1495
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645