Literature DB >> 15571376

A strong positive dendritic effect in a peptide dendrimer-catalyzed ester hydrolysis reaction.

Estelle Delort1, Tamis Darbre, Jean-Louis Reymond.   

Abstract

The contribution of the dendritic structure in catalysis of ester hydrolysis was investigated with a systematic peptide dendrimer series of increasing generation number (G1-G4) containing a catalytic consensus sequence His-Ser in all branches. A strong positive dendritic effect was observed with up to 100-fold increased histidine reactivity between G1 and G4. Kinetic studies and isothermal calorimetric titration experiments showed that the strong positive dendritic effect resulted from cooperativity between binding and catalysis.

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Year:  2004        PMID： 15571376     DOI： 10.1021/ja044652p

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  11 in total

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