Literature DB >> 15570382

Design and evaluation of a Dean vortex-based micromixer.

Peter B Howell1, David R Mott, Joel P Golden, Frances S Ligler.   

Abstract

A mixer, based on the Dean vortex, is fabricated and tested in an on-chip format. When fluid is directed around a curve under pressure driven flow, the high velocity streams in the center of the channel experience a greater centripetal force and so are deflected outward. This creates a pair of counter-rotating vortices moving fluid toward the inner wall at the top and bottom of the channel and toward the outer wall in the center. For the geometries studied, the vortices were first seen at Reynolds numbers between 1 and 10 and became stronger as the flow velocity is increased. Vortex formation was monitored in channels with depth/width ratios of 0.5, 1.0, and 2.0. The lowest aspect ratio strongly suppressed vortex formation. Increasing the aspect ratio above 1 appeared to provide improved mixing. This design has the advantages of easy fabrication and low surface area.

Mesh:

Year:  2004        PMID: 15570382     DOI: 10.1039/b407170k

Source DB:  PubMed          Journal:  Lab Chip        ISSN: 1473-0189            Impact factor:   6.799


  12 in total

1.  Hydrodynamic focusing--a versatile tool.

Authors:  Joel P Golden; Gusphyl A Justin; Mansoor Nasir; Frances S Ligler
Journal:  Anal Bioanal Chem       Date:  2011-09-29       Impact factor: 4.142

2.  Multivortex micromixing.

Authors:  Arjun P Sudarsan; Victor M Ugaz
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-27       Impact factor: 11.205

3.  A practical guide to the staggered herringbone mixer.

Authors:  Manda S Williams; Kenneth J Longmuir; Paul Yager
Journal:  Lab Chip       Date:  2008-05-23       Impact factor: 6.799

Review 4.  Controlling mass transport in microfluidic devices.

Authors:  Jason S Kuo; Daniel T Chiu
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2011       Impact factor: 10.745

5.  Optimal self-assembly of lipid nanoparticles (LNP) in a ring micromixer.

Authors:  Manon Ripoll; Elian Martin; Mathilde Enot; Oscar Robbe; Chiara Rapisarda; Marie-Claire Nicolai; Aurélie Deliot; Patrick Tabeling; Jean-René Authelin; Mostafa Nakach; Pierre Wils
Journal:  Sci Rep       Date:  2022-06-08       Impact factor: 4.996

6.  Optimal designs of staggered dean vortex micromixers.

Authors:  Jyh Jian Chen; Chun Huei Chen; Shian Ruei Shie
Journal:  Int J Mol Sci       Date:  2011-06-03       Impact factor: 5.923

7.  Numerical simulation on the effects of drug eluting stents at different Reynolds numbers on hemodynamic and drug concentration distribution.

Authors:  Yu Chen; Yan Xiong; Wentao Jiang; Fei Yan; Meng Guo; Qingyuan Wang; Yubo Fan
Journal:  Biomed Eng Online       Date:  2015-01-09       Impact factor: 2.819

Review 8.  Microfluidic devices: useful tools for bioprocess intensification.

Authors:  Marco P C Marques; Pedro Fernandes
Journal:  Molecules       Date:  2011-09-30       Impact factor: 4.411

Review 9.  A Review of Secondary Flow in Inertial Microfluidics.

Authors:  Qianbin Zhao; Dan Yuan; Jun Zhang; Weihua Li
Journal:  Micromachines (Basel)       Date:  2020-04-28       Impact factor: 2.891

10.  Dean Flow Dynamics in Low-Aspect Ratio Spiral Microchannels.

Authors:  Nivedita Nivedita; Phillip Ligrani; Ian Papautsky
Journal:  Sci Rep       Date:  2017-03-10       Impact factor: 4.379

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