Literature DB >> 15567169

Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice.

Yuji Tanaka1, Angela L Slitt, Tyra M Leazer, Jonathan M Maher, Curtis D Klaassen.   

Abstract

Breast cancer resistance protein (Bcrp/Abcg2) is a member of the ABC transporter family. The purpose of this study was to quantify Bcrp mRNA in rat and mouse tissues, and to determine whether there are gender differences in Bcrp mRNA expression. Rat Bcrp mRNA levels were high in intestine and male kidney, and intermediate in testes. Mouse Bcrp expression was highest in kidney, followed by liver, ileum, and testes. Male-predominant expression of Bcrp was observed in rat kidney and mouse liver. Furthermore, gonadectomy and hypophysectomy experiments were conducted to determine whether sex steroids and/or growth hormone are responsible for Bcrp gender-divergent expression patterns. Male-predominant expression of Bcrp in rat kidney appears to be due to the suppressive effect of estradiol, and male-predominant expression of Bcrp in mouse liver appears to be due to the inductive effect of testosterone.

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Year:  2005        PMID： 15567169     DOI： 10.1016/j.bbrc.2004.11.012

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  52 in total

1.  5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice.

Authors:  Guohua An; Fang Wu; Marilyn E Morris
Journal:  Pharm Res       Date:  2011-01-29       Impact factor: 4.200

2.  Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice.

Authors:  Zidong Donna Fu; Iván L Csanaky; Curtis D Klaassen
Journal:  Drug Metab Dispos       Date:  2012-03-23       Impact factor: 3.922

3.  Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier.

Authors:  G Moreno-Sanz; O Sasso; A Guijarro; O Oluyemi; R Bertorelli; A Reggiani; D Piomelli
Journal:  Br J Pharmacol       Date:  2012-12       Impact factor: 8.739

Review 4.  Advances in predictive in vitro models of drug-induced nephrotoxicity.

Authors:  Joanne Y-C Soo; Jitske Jansen; Rosalinde Masereeuw; Melissa H Little
Journal:  Nat Rev Nephrol       Date:  2018-06       Impact factor: 28.314

Review 5.  ABCG transporters and disease.

Authors:  Owen M Woodward; Anna Köttgen; Michael Köttgen
Journal:  FEBS J       Date:  2011-06-13       Impact factor: 5.542

Review 6.  Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain.

Authors:  Sagar Agarwal; Ramola Sane; Rajneet Oberoi; John R Ohlfest; William F Elmquist
Journal:  Expert Rev Mol Med       Date:  2011-05-13       Impact factor: 5.600

Review 7.  Interaction of Isoflavones with the BCRP/ABCG2 Drug Transporter.

Authors:  Kristin M Bircsak; Lauren M Aleksunes
Journal:  Curr Drug Metab       Date:  2015       Impact factor: 3.731

8.  ATP-binding cassette transporter G2 activity in the bovine spermatozoa is modulated along the epididymal duct and at ejaculation.

Authors:  Julieta Caballero; Gilles Frenette; Olivier D'Amours; Maurice Dufour; Richard Oko; Robert Sullivan
Journal:  Biol Reprod       Date:  2012-06-14       Impact factor: 4.285

Review 9.  Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules.

Authors:  Rosalinde Masereeuw; Frans G M Russel
Journal:  AAPS J       Date:  2012-09-08       Impact factor: 4.009

10.  Prominent expression of xenobiotic efflux transporters in mouse extraembryonic fetal membranes compared with placenta.

Authors:  Lauren M Aleksunes; Yue Cui; Curtis D Klaassen
Journal:  Drug Metab Dispos       Date:  2008-06-19       Impact factor: 3.922
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