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Literature DB >> 22961390

Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules.

Abstract

The ATP-binding cassette transport proteins (ABC transporters) represent important determinants of drug excretion. Protective or excretory tissues where these transporters mediate substrate efflux include the kidney proximal tubule. Regulation of the transport proteins in this tissue requires elaborate signaling pathways, including genetic, epigenetic, nuclear receptor mediated, posttranscriptional gene regulation involving microRNAs, and non-genomic (kinases) pathways triggered by hormones and/or growth factors. This review discusses current knowledge on regulatory pathways for ABC transporters in kidney proximal tubules, with a main focus on P-glycoprotein, multidrug resistance proteins 2 and 4, and breast cancer resistance protein. Insight in these processes is of importance because variations in transporter activity due to certain (disease) conditions could lead to significant changes in drug efficacy or toxicity.

Entities: Disease Gene

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Year: 2012 PMID： 22961390 PMCID： PMC3475864 DOI： 10.1208/s12248-012-9404-z

Source DB: PubMed Journal: AAPS J ISSN： 1550-7416 Impact factor: 4.009

97 in total

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Journal: Perit Dial Int Date: 2010-03-25 Impact factor: 1.756

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Journal: Nat Rev Drug Discov Date: 2010-03 Impact factor: 84.694

4. Aryl hydrocarbon receptor is a transcriptional activator of the human breast cancer resistance protein (BCRP/ABCG2).

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Journal: Mol Pharmacol Date: 2010-05-11 Impact factor: 4.436

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Journal: Cell Tissue Res Date: 2012-05-13 Impact factor: 5.249

13 in total

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Authors: Tyler J Kochel; Amy M Fulton
Journal: Prostaglandins Other Lipid Mediat Date: 2014-11-27 Impact factor: 3.072

Review 2. Nucleotide Reverse Transcriptase Inhibitors: A Thorough Review, Present Status and Future Perspective as HIV Therapeutics.

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Journal: Curr HIV Res Date: 2017 Impact factor: 1.581

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Journal: Clin Pharmacol Ther Date: 2018-07-12 Impact factor: 6.875

4. Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules.

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Journal: AAPS J Date: 2018-08-14 Impact factor: 4.009

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Authors: Sanjay K Nigam; Wei Wu; Kevin T Bush; Melanie P Hoenig; Roland C Blantz; Vibha Bhatnagar
Journal: Clin J Am Soc Nephrol Date: 2015-10-21 Impact factor: 8.237

6. Amelioration of Diabetic Nephropathy by Targeting Autophagy via Rapamycin or Fasting: Relation to Cell Apoptosis/Survival.

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Journal: Curr Issues Mol Biol Date: 2021-10-22 Impact factor: 2.976

7. Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently.

Authors: Carolien M S Schophuizen; Joost G J Hoenderop; Rosalinde Masereeuw; Lambert P van den Heuvel
Journal: Cells Date: 2015-06-26 Impact factor: 6.600

8. Three dimensional modeling of biologically relevant fluid shear stress in human renal tubule cells mimics in vivo transcriptional profiles.

Authors: Emily J Ross; Emily R Gordon; Hanna Sothers; Roshan Darji; Oakley Baron; Dustin Haithcock; Balabhaskar Prabhakarpandian; Kapil Pant; Richard M Myers; Sara J Cooper; Nancy J Cox
Journal: Sci Rep Date: 2021-07-07 Impact factor: 4.379

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Journal: In Silico Pharmacol Date: 2015-09-04

Review 10. Crosstalk Between Lipids and Mitochondria in Diabetic Kidney Disease.

Authors: G Michelle Ducasa; Alla Mitrofanova; Alessia Fornoni
Journal: Curr Diab Rep Date: 2019-11-21 Impact factor: 5.430