Literature DB >> 15566297

Effects of indole fatty alcohols on the differentiation of neural stem cell derived neurospheres.

Djalil Coowar1, Julien Bouissac, Mazen Hanbali, Marie Paschaki, Eliane Mohier, Bang Luu.   

Abstract

In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13c (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.

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Year:  2004        PMID： 15566297     DOI： 10.1021/jm0493616

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  9 in total

1.  Chemicals possessing a neurotrophin-like activity on dopaminergic neurons in primary culture.

Authors:  Fanny Schmidt; Pierre Champy; Blandine Séon-Méniel; Xavier Franck; Rita Raisman-Vozari; Bruno Figadère
Journal:  PLoS One       Date:  2009-07-10       Impact factor: 3.240

2.  Differential patterns of NOTCH1-4 receptor expression are markers of glioma cell differentiation.

Authors:  Paola Dell'albani; Margherita Rodolico; Rosalia Pellitteri; Elisa Tricarichi; Sebastiano Alfio Torrisi; Simona D'Antoni; Mario Zappia; Vincenzo Albanese; Rosario Caltabiano; Nunzio Platania; Eleonora Aronica; Maria Vincenza Catania
Journal:  Neuro Oncol       Date:  2013-12-04       Impact factor: 12.300

3.  Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; Olga Cruz-Lopez; Carlota Lopez Cara; Delia Preti; Mojgan Aghazadeh Tabrizi; Jan Balzarini; Ernest Hamel; Enrica Fabbri; Roberto Gambari
Journal:  Lett Drug Des Discov       Date:  2009-06-01       Impact factor: 1.150

4.  Synthesis and anti-tuberculosis activity of the marine natural product caulerpin and its analogues.

Authors:  Cristina I Canché Chay; Rocío Gómez Cansino; Clara I Espitia Pinzón; Rubén O Torres-Ochoa; Roberto Martínez
Journal:  Mar Drugs       Date:  2014-03-27       Impact factor: 5.118

5.  Synthesis and biological evaluation of indolyl-pyridinyl-propenones having either methuosis or microtubule disruption activity.

Authors:  Christopher J Trabbic; Jean H Overmeyer; Evan M Alexander; Emily J Crissman; Heather M Kvale; Marcie A Smith; Paul W Erhardt; William A Maltese
Journal:  J Med Chem       Date:  2015-02-19       Impact factor: 7.446

6.  Structural necessity of indole C5-O-substitution of seco-duocarmycin analogs for their cytotoxic activity.

Authors:  Taeyoung Choi; Eunsook Ma
Journal:  Molecules       Date:  2010-11-08       Impact factor: 4.411

7.  Synthesis, Spectroscopic Characterization and Antimicrobial Potential of Certain New Isatin-Indole Molecular Hybrids.

Authors:  Reem I Al-Wabli; Azza S Zakaria; Mohamed I Attia
Journal:  Molecules       Date:  2017-11-15       Impact factor: 4.411

8.  Design, Synthesis, and Antimicrobial Activity of Certain New Indole-1,2,4 Triazole Conjugates.

Authors:  Reem I Al-Wabli; Mona A Alsulami; Sarah I Bukhari; Nadine M S Moubayed; Maha S Al-Mutairi; Mohamed I Attia
Journal:  Molecules       Date:  2021-04-15       Impact factor: 4.411

9.  Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach.

Authors:  Delia Preti; Romeo Romagnoli; Riccardo Rondanin; Barbara Cacciari; Ernest Hamel; Jan Balzarini; Sandra Liekens; Dominique Schols; Francisco Estévez-Sarmiento; José Quintana; Francisco Estévez
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051
  9 in total

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