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Literature DB >> 15564517

Infectious molecular clone of a recently transmitted pediatric human immunodeficiency virus clade C isolate from Africa: evidence of intraclade recombination.

Ricky D Grisson¹, Agnès-Laurence Chenine, Lan-Yu Yeh, Jun He, Charles Wood, Ganapati J Bhat, Weidong Xu, Chipepo Kankasa, Ruth M Ruprecht.

Abstract

Although human immunodeficiency virus type 1 (HIV-1) clade C continues to dominate the pandemic, only two infectious clade C proviral DNA clones have been described (N. Mochizuki, N. Otsuka, K. Matsuo, T. Shiino, A. Kojima, T. Kurata, K. Sakai, N. Yamamoto, S. Isomura, T. N. Dhole, Y. Takebe, M. Matsuda, and M. Tatsumi, AIDS Res. Hum. Retrovir. 15:1321-1324, 1999; T. Ndung'u, B. Renjifo, and M. Essex, J. Virol. 75:4964-4972, 2001). We have generated an infectious molecular clone of a pediatric clade C strain, HIV1084i, which was isolated from a Zambian infant infected either intrapartum or through breastfeeding. HIV1084i is an R5, non-syncytium-inducing isolate that bears all known clade C signatures; gag, pol, and env consistently mapped within clade C. Interestingly, gag resembled Asian isolates, whereas pol and env resembled African isolates, indicating that HIV1084i probably arose from an intraclade recombination. As a recently transmitted clade C strain, HIV1084i will be a useful vaccine development tool.

Entities: Disease Gene Species

Mesh：

Year: 2004 PMID： 15564517 PMCID： PMC533957 DOI： 10.1128/JVI.78.24.14066-14069.2004

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

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