Literature DB >> 15563568

Influence of race on kidney transplant outcomes within and outside the Department of Veterans Affairs.

Harini A Chakkera1, Ann M O'Hare, Kirsten L Johansen, Denise Hynes, Kevin Stroupe, Philip M Colin, Glenn M Chertow.   

Abstract

Inferior outcomes after kidney transplantation among African Americans are poorly understood. It was hypothesized that unequal access to medical care among transplant recipients might contribute to worse posttransplantation outcomes among African Americans and that racial disparities in kidney transplant outcomes would be less pronounced among patients who receive health care within versus outside the Department of Veterans Affairs (VA), because eligible veterans who receive care within the VA are entitled to receive universal access to care, including coverage of prescription drugs. A study cohort of 79,361 patients who were undergoing their first kidney transplant in the United States between October 1, 1991, and October 31, 2000, was assembled, with follow-up data on graft survival obtained through October 31, 2001. After multivariable proportional hazards adjustment for a wide range of recipient and donor characteristics, African-American patients were at increased risk for graft failure compared with non-African-American patients (relative risk [RR] 1.31; 95% confidence interval [CI] 1.26 to 1.36). African-American race was associated with a similarly increased risk for graft failure among patients who were VA users (RR 1.31; 95% CI 1.11 to 1.54) and non-VA users (RR 1.31; 95% CI 1.26 to 1.36). In conclusion, racial disparities in kidney transplant outcomes seem to persist even in a universal access-to-care system such as the VA. Reasons for worse outcomes among African Americans require further investigation.

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Mesh:

Year:  2004        PMID: 15563568     DOI: 10.1681/ASN.2004040333

Source DB:  PubMed          Journal:  J Am Soc Nephrol        ISSN: 1046-6673            Impact factor:   10.121


  47 in total

Review 1.  Disparities in kidney transplant outcomes: a review.

Authors:  Elisa J Gordon; Daniela P Ladner; Juan Carlos Caicedo; John Franklin
Journal:  Semin Nephrol       Date:  2010-01       Impact factor: 5.299

Review 2.  Target organ damage in African American hypertension: role of APOL1.

Authors:  Barry I Freedman; Mariana Murea
Journal:  Curr Hypertens Rep       Date:  2012-02       Impact factor: 5.369

3.  Electronically measured adherence to immunosuppressive medications and kidney function after deceased donor kidney transplantation.

Authors:  Ajay K Israni; Francis L Weng; Ye-Ying Cen; Marshall Joffe; Malek Kamoun; Harold I Feldman
Journal:  Clin Transplant       Date:  2010-10-26       Impact factor: 2.863

4.  African American kidney transplantation survival: the ability of immunosuppression to balance the inherent pre- and post-transplant risk factors.

Authors:  Gregory E Malat; Christine Culkin; Aniruddha Palya; Karthik Ranganna; Mysore S Anil Kumar
Journal:  Drugs       Date:  2009-10-22       Impact factor: 9.546

5.  The Risk of Transplant Failure With HLA Mismatch in First Adult Kidney Allografts From Deceased Donors.

Authors:  Robert C Williams; Gerhard Opelz; Chelsea J McGarvey; E Jennifer Weil; Harini A Chakkera
Journal:  Transplantation       Date:  2016-05       Impact factor: 4.939

6.  Overall Graft Loss Versus Death-Censored Graft Loss: Unmasking the Magnitude of Racial Disparities in Outcomes Among US Kidney Transplant Recipients.

Authors:  David J Taber; Mulugeta Gebregziabher; Elizabeth H Payne; Titte Srinivas; Prabhakar K Baliga; Leonard E Egede
Journal:  Transplantation       Date:  2017-02       Impact factor: 4.939

7.  Comparing VA to Non-VA Care.

Authors:  William B Weeks
Journal:  J Gen Intern Med       Date:  2017-02       Impact factor: 5.128

8.  Impact of race on cumulative exposure to antihypertensive medications in dialysis.

Authors:  James B Wetmore; Jonathan D Mahnken; Sally K Rigler; Edward F Ellerbeck; Purna Mukhopadhyay; Qingjiang Hou; Theresa I Shireman
Journal:  Am J Hypertens       Date:  2012-12-28       Impact factor: 2.689

9.  Impact of Cardiovascular Risk Factors on Graft Outcome Disparities in Black Kidney Transplant Recipients.

Authors:  David J Taber; Kelly J Hunt; Cory E Fominaya; Elizabeth H Payne; Mulugeta Gebregziabher; Titte R Srinivas; Prabhakar K Baliga; Leonard E Egede
Journal:  Hypertension       Date:  2016-07-11       Impact factor: 10.190

10.  Significant racial differences in the key factors associated with early graft loss in kidney transplant recipients.

Authors:  David J Taber; Kevin Douglass; Titte Srinivas; John W McGillicuddy; Charles F Bratton; Kenneth D Chavin; Prabhakar K Baliga; Leonard E Egede
Journal:  Am J Nephrol       Date:  2014-06-25       Impact factor: 3.754

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