Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 New cholesterol biosynthesis inhibitors MC-031 (O-demethylchlorothricin), -032 (O-demethylhydroxychlorothricin), -033 and -034.

Literature DB >> 1556012

New cholesterol biosynthesis inhibitors MC-031 (O-demethylchlorothricin), -032 (O-demethylhydroxychlorothricin), -033 and -034.

A Kawashima¹, Y Nakamura, Y Ohta, T Akama, M Yamagishi, K Hanada.

Abstract

In the course of our screening for microbial compounds which possessed inhibitory activities against biosynthesis of cholesterol from mevalonate, we isolated four new compounds from the cultural broth of Streptomyces sp. A7361. They are structurally related to, but distinct from chlorothricin.

Entities: Chemical

Mesh：

Substances：

Year: 1992 PMID： 1556012 DOI： 10.7164/antibiotics.45.207

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

Keyword Cloud
Cited

7 in total

1. A concise total synthesis of (±)- and (-)-okilactomycin D.

Authors: Dawen Niu; Thomas R Hoye
Journal: Org Lett Date: 2012-01-24 Impact factor: 6.005

Review 2. A comprehensive review of glycosylated bacterial natural products.

Authors: Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal: Chem Soc Rev Date: 2015-11-07 Impact factor: 54.564

Review 3. Type II non-ribosomal peptide synthetase proteins: structure, mechanism, and protein-protein interactions.

Authors: Matt J Jaremko; Tony D Davis; Joshua C Corpuz; Michael D Burkart
Journal: Nat Prod Rep Date: 2020-03-25 Impact factor: 13.423

4. Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.

Authors: Hua Zhang; Jess A White-Phillip; Charles E Melançon; Hyung-jin Kwon; Wei-luen Yu; Hung-wen Liu
Journal: J Am Chem Soc Date: 2007-11-07 Impact factor: 15.419

New cholesterol biosynthesis inhibitors MC-031 (O-demethylchlorothricin), -032 (O-demethylhydroxychlorothricin), -033 and -034.

1. A concise total synthesis of (±)- and (-)-okilactomycin D.

Review 2. A comprehensive review of glycosylated bacterial natural products.

Review 3. Type II non-ribosomal peptide synthetase proteins: structure, mechanism, and protein-protein interactions.

4. Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.

5. Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL.

Review 6. Spirotetronate polyketides as leads in drug discovery.

7. Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4.