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Literature DB >> 15560013

A proof that uniform dose gives the greatest TCP for fixed integral dose in the planning target volume.

S Webb¹, P M Evans, W Swindell, J O Deasy.

Abstract

In this note it is shown that for a fixed integral dose to the planning target volume, the highest tumour control probability (TCP) arises when the dose is spatially uniform. This 'uniform dose theorem' is proved both for (i) a specific TCP model based on Poisson/independent voxel statistics, and (ii) any model for voxel control probability having a specific shape with respect to increasing dose.

Entities: Chemical Disease

Mesh：

Year: 1994 PMID： 15560013 DOI： 10.1088/0031-9155/39/11/018

Source DB: PubMed Journal: Phys Med Biol ISSN： 0031-9155 Impact factor: 3.609

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Cited

9 in total

1. Dosimetric and radiobiological comparison of helical tomotherapy, forward-planned intensity-modulated radiotherapy and two-phase conformal plans for radical radiotherapy treatment of head and neck squamous cell carcinomas.

Authors: S Chatterjee; N Willis; S M Locks; J H Mott; C G Kelly
Journal: Br J Radiol Date: 2011-12 Impact factor: 3.039

9. Reducing dose to the lungs through loosing target dose homogeneity requirement for radiotherapy of non small cell lung cancer.

Authors: Junjie Miao; Hui Yan; Yuan Tian; Pan Ma; Zhiqiang Liu; Minghui Li; Wenting Ren; Jiayun Chen; Ye Zhang; Jianrong Dai
Journal: J Appl Clin Med Phys Date: 2017-10-11 Impact factor: 2.102

9 in total

A proof that uniform dose gives the greatest TCP for fixed integral dose in the planning target volume.

1. Dosimetric and radiobiological comparison of helical tomotherapy, forward-planned intensity-modulated radiotherapy and two-phase conformal plans for radical radiotherapy treatment of head and neck squamous cell carcinomas.

2. Modelling responses to spatially fractionated radiation fields using preclinical image-guided radiotherapy.

Review 3. Molecular imaging-based dose painting: a novel paradigm for radiation therapy prescription.

4. Feasibility of dose painting using volumetric modulated arc optimization and delivery.

5. Spatial optimization for radiation therapy of brain tumours.

6. Adaptive dose painting for prostate cancer.

7. Use of an orthovoltage X-ray treatment unit as a radiation research system in a small-animal cancer model.

8. Qualitative dosimetric and radiobiological evaluation of high - dose - rate interstitial brachytherapy implants.

9. Reducing dose to the lungs through loosing target dose homogeneity requirement for radiotherapy of non small cell lung cancer.