Literature DB >> 15558946

Inhibitory activity of cyanidin-3-rutinoside on alpha-glucosidase.

Sirichai Adisakwattana1, Nattaya Ngamrojanavanich, Kanyarat Kalampakorn, Wilaiwon Tiravanit, Sophon Roengsumran, Sirintorn Yibchok-Anun.   

Abstract

Cyanidin-3-rutinoside, a natural anthocyanin, inhibited alpha-glucosidase from baker's yeast in dose-responsive manner. The IC50 value was 19.7 microM +/- 0.24 microM, compared with the IC50 value of voglibose (IC50 = 23.4 +/- 0.30 microM). Cyanidin-3-rutinoside was found to be a non-competitive inhibitor for yeast alpha-glucosidase with a Ki value in the range of 1.31-1.56 x 10(-5)M. These results indicated that cyanidin-3-rutinoside could be classed as a new alpha-glucosidase inhibitor.

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Year:  2004        PMID： 15558946     DOI： 10.1080/14756360409162443

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  7 in total

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2.  Inhibitory activities of cyanidin and its glycosides and synergistic effect with acarbose against intestinal α-glucosidase and pancreatic α-amylase.

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3.  Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal α-glucosidase.

Authors:  Sirichai Adisakwattana; Sirintorn Yibchok-Anun; Piyawan Charoenlertkul; Natthakarn Wongsasiripat
Journal:  J Clin Biochem Nutr       Date:  2011-05-24       Impact factor: 3.114

4.  Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations.

Authors:  Monica L Castro-Acosta; Leanne Smith; Rosalind J Miller; Danielle I McCarthy; Jonathan A Farrimond; Wendy L Hall
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5.  In vitro inhibitory effects of cyandin-3-rutinoside on pancreatic α-amylase and its combined effect with acarbose.

Authors:  Sarinya Akkarachiyasit; Sirintorn Yibchok-Anun; Sumrit Wacharasindhu; Sirichai Adisakwattana
Journal:  Molecules       Date:  2011-03-02       Impact factor: 4.411

6.  Inhibition of protein tyrosine phosphatase (PTP1B) and α-glucosidase by geranylated flavonoids from Paulownia tomentosa.

Authors:  Yeong Hun Song; Zia Uddin; Young Min Jin; Zuopeng Li; Marcus John Curtis-Long; Kwang Dong Kim; Jung Keun Cho; Ki Hun Park
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051

7.  A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36 % wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle.

Authors:  Nigel Hoggard; Morven Cruickshank; Kim-Marie Moar; Charles Bestwick; Jens J Holst; Wendy Russell; Graham Horgan
Journal:  J Nutr Sci       Date:  2013-07-24
  7 in total

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