| Literature DB >> 15552401 |
V R A Pereira1, V M B Lorena, A P Galvao Da Silva, E M Coutinho, E D Silvas, A G P Ferreira, P Miranda, M A Krieger, S Goldenberg, M B P Soares, R Correa-Oliveira, Y M Gomes.
Abstract
In previous studies, we demonstrated that CRA and FRA recombinant proteins, used for diagnosis of Chagas' disease, elicited a humoral immune response in susceptible and resistant mice. To understand better the immune response to these proteins, we have evaluated, the cellular immune response in CRA- and in FRA-immunized BALB/c and C57BL/6 mice. A specific cellular lymphoproliferative response was observed in both strains of mice. Spleen cell cultures mainly from CRA-immunized C57BL/6 and FRA-immunized BALB/c mice produced high levels of IFN-y, indicating the induction of a Type 1 immune response. Regarding the T cell subsets, CD4+ T cells were the major source of IFN-y in CRA- and FRA-immunized mice. These results suggest that CRA and FRA are important immunogens in inducing a Type 1 immune response and that they may be considered as potential vaccine antigens.Entities:
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Year: 2004 PMID： 15552401 DOI： 10.1017/s0031182004006043
Source DB: PubMed Journal: Parasitology ISSN： 0031-1820 Impact factor: 3.234