| Literature DB >> 15551389 |
Vinay K Sharma1, Jinsuk Choi, Niti Sharma, Mieyoung Choi, Sung-Yum Seo.
Abstract
The inhibition of mushroom tyrosinase by methanolic extract of Dictyophora indusiata was evaluated and the bioactive component was characterized and identified as 5-(hydroxymethyl)-2-furfural (HMF) by chromatographic and spectroscopic means. Kinetic studies revealed it to be a noncompetitive inhibitor for the oxidation of L-DOPA. On the basis of these findings some related analogues were also tested for their anti-tyrosinase activity, in order to gain more insight into structure and activity relationship among these heterocyclic compounds. Copyright 2004 John Wiley & Sons, Ltd.Entities:
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Year: 2004 PMID: 15551389 DOI: 10.1002/ptr.1428
Source DB: PubMed Journal: Phytother Res ISSN: 0951-418X Impact factor: 5.878