Literature DB >> 15549250

[Telomerase activity and telomere length of human mesenchymal stem cells. Changes during osteogenic differentiation].

M Schieker1, H Gülkan, B Austrup, P Neth, W Mutschler.   

Abstract

Human mesenchymal stem cells (hMSC) exhibit properties of self-renewal and differentiation. Assuming that telomerase activity is associated with self-renewal, it might be useful to identify and define hMSC on the basis of their telomerase status. However, telomerase activity in hMSC remains a controversial issue. Therefore, the aim of our study was to investigate telomerase activity in proliferating and highly proliferating hMSC and to measure telomerase activity and changes in telomere restriction fragment (TRF) length of confluent hMSC and of osteogenically differentiated hMSC. For tissue engineering applications scaffolds should be seeded with cells that have not lost their ability to self-replicate and differentiate during in vitro cell culture. Telomerase activity could be used to characterise and isolate these cells.

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Year:  2004        PMID： 15549250     DOI： 10.1007/s00132-004-0739-8

Source DB:  PubMed          Journal:  Orthopade        ISSN： 0085-4530            Impact factor:   1.087


  16 in total

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Journal:  J Cell Physiol       Date:  1999-10       Impact factor: 6.384

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Journal:  J Bone Miner Res       Date:  2003-04       Impact factor: 6.741

3.  The use of four-colour immunofluorescence techniques to identify mesenchymal stem cells.

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Journal:  J Anat       Date:  2004-02       Impact factor: 2.610

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Journal:  Cell       Date:  1989-11-03       Impact factor: 41.582

Review 5.  Telomerase activity in human cancer.

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Journal:  Curr Opin Oncol       Date:  1996-01       Impact factor: 3.645

6.  Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells.

Authors:  Janne L Simonsen; Cecilia Rosada; Nedime Serakinci; Jeannette Justesen; Karin Stenderup; Suresh I S Rattan; Thomas G Jensen; Moustapha Kassem
Journal:  Nat Biotechnol       Date:  2002-06       Impact factor: 54.908

7.  Telomeres shorten during ageing of human fibroblasts.

Authors:  C B Harley; A B Futcher; C W Greider
Journal:  Nature       Date:  1990-05-31       Impact factor: 49.962

8.  Clonal population of adult stem cells: life span and differentiation potential.

Authors:  Mitchel Seruya; Anup Shah; Dawn Pedrotty; Tracey du Laney; Ryan Melgiri; J Andrew McKee; Henry E Young; Laura E Niklason
Journal:  Cell Transplant       Date:  2004       Impact factor: 4.064

9.  Specific association of human telomerase activity with immortal cells and cancer.

Authors:  N W Kim; M A Piatyszek; K R Prowse; C B Harley; M D West; P L Ho; G M Coviello; W E Wright; S L Weinrich; J W Shay
Journal:  Science       Date:  1994-12-23       Impact factor: 47.728

10.  Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes.

Authors:  Dominik Parsch; Jörg Fellenberg; Tim H Brümmendorf; Anna-Maria Eschlbeck; Wiltrud Richter
Journal:  J Mol Med (Berl)       Date:  2003-11-28       Impact factor: 4.599
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  6 in total

Review 1.  Stem cell function and maintenance - ends that matter: role of telomeres and telomerase.

Authors:  Hamid Saeed; Mehwish Iqtedar
Journal:  J Biosci       Date:  2013-09       Impact factor: 1.826

Review 2.  The Role of Ubiquitination and SUMOylation in Telomere Biology.

Authors:  Michal Zalzman; W Alex Meltzer; Benjamin A Portney; Robert A Brown; Aditi Gupta
Journal:  Curr Issues Mol Biol       Date:  2019-08-18       Impact factor: 2.081

3.  Increased expression of importin13 in endometriosis and endometrial carcinoma.

Authors:  Biao Zeng; Jianguo Hu; Rui Yuan; LiNa Hu; Ling Zhong; Kai Kang
Journal:  Med Sci Monit       Date:  2012-06

4.  Decreased expression of c-kit and telomerase in a rat model of chronic endometrial ischemia.

Authors:  Jianguo Hu; Rui Yuan
Journal:  Med Sci Monit       Date:  2011-04

5.  Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers.

Authors:  Khanit Sa-ngiamsuntorn; Adisak Wongkajornsilp; Kanda Kasetsinsombat; Sunisa Duangsa-ard; Lalana Nuntakarn; Suparerk Borwornpinyo; Pravit Akarasereenont; Somchai Limsrichamrern; Suradej Hongeng
Journal:  BMC Biotechnol       Date:  2011-09-30       Impact factor: 2.563

6.  Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer.

Authors:  Wolfgang Böcker; Zhanhai Yin; Inga Drosse; Florian Haasters; Oliver Rossmann; Matthias Wierer; Cvetan Popov; Melanie Locher; Wolf Mutschler; Denitsa Docheva; Matthias Schieker
Journal:  J Cell Mol Med       Date:  2008-03-04       Impact factor: 5.310
  6 in total

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