Literature DB >> 23938394

Stem cell function and maintenance - ends that matter: role of telomeres and telomerase.

Hamid Saeed1, Mehwish Iqtedar.   

Abstract

Stem cell research holds a promise to treat and prevent age-related degenerative changes in humans. Literature is replete with studies showing that stem cell function declines with aging, especially in highly proliferative tissues/ organs. Among others, telomerase and telomere damage is one of the intrinsic physical instigators that drive agerelated degenerative changes. In this review we provide brief overview of telomerase-deficient aging affects in diverse stem cells populations. Furthermore, potential disease phenotypes associated with telomerase dysregulation in a specific stem cell population is also discussed in this review. Additionally, the role of telomerase in stem cell driven cancer is also briefly touched upon.

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Year:  2013        PMID： 23938394     DOI： 10.1007/s12038-013-9346-3

Source DB:  PubMed          Journal:  J Biosci        ISSN： 0250-5991            Impact factor:   1.826


  110 in total

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Authors:  Ergün Sahin; Ronald A Depinho
Journal:  Nature       Date:  2010-03-25       Impact factor: 49.962

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Journal:  J Mol Biol       Date:  1978-03-25       Impact factor: 5.469

3.  Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

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4.  Replicative aging of human articular chondrocytes during ex vivo expansion.

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Journal:  Arthritis Rheum       Date:  2002-11

Review 5.  Adult bone marrow stem cells for cell and gene therapies: implications for greater use.

Authors:  Christopher B Ballas; Steven P Zielske; Stanton L Gerson
Journal:  J Cell Biochem Suppl       Date:  2002

6.  Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.

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Journal:  AIDS       Date:  1996-07       Impact factor: 4.177

7.  Cell cycle dependent telomere regulation by telomerase in human bone marrow mesenchymal stem cells.

Authors:  Yan-Min Zhao; Jing-Yuan Li; Jian-Ping Lan; Xiao-Yu Lai; Yi Luo; Jie Sun; Jian Yu; Yuan-Yuan Zhu; Fen-Fang Zeng; Qian Zhou; He Huang
Journal:  Biochem Biophys Res Commun       Date:  2008-03-11       Impact factor: 3.575

Review 8.  Age-related cognitive decline: can neural stem cells help us?

Authors:  Benedetta Artegiani; Federico Calegari
Journal:  Aging (Albany NY)       Date:  2012-03       Impact factor: 5.682

Review 9.  Mechanisms underlying the osteo- and adipo-differentiation of human mesenchymal stem cells.

Authors:  Yu Zhang; Dilaware Khan; Julia Delling; Edda Tobiasch
Journal:  ScientificWorldJournal       Date:  2012-03-12

10.  Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.

Authors:  Silvia Espejel; Peter Klatt; Josiane Ménissier-de Murcia; Juan Martín-Caballero; Juana M Flores; Guillermo Taccioli; Gilbert de Murcia; María A Blasco
Journal:  J Cell Biol       Date:  2004-11-15       Impact factor: 10.539
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  5 in total

Review 1.  Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential.

Authors:  Kivanc Atesok; Freddie H Fu; Ichiro Sekiya; Alexandra Stolzing; Mitsuo Ochi; Scott A Rodeo
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2015-08-23       Impact factor: 4.342

2.  STEEx, a boundary between the world of quiescence and the vegetative cycle.

Authors:  Laetitia Maestroni; Vincent Géli; Stéphane Coulon
Journal:  Curr Genet       Date:  2018-02-01       Impact factor: 3.886

Review 3.  Adult stem cell and mesenchymal progenitor theories of aging.

Authors:  So-Ichiro Fukada; Yuran Ma; Akiyoshi Uezumi
Journal:  Front Cell Dev Biol       Date:  2014-03-28

4.  Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences.

Authors:  Laetitia Maestroni; Julien Audry; Samah Matmati; Benoit Arcangioli; Vincent Géli; Stéphane Coulon
Journal:  Nat Commun       Date:  2017-11-22       Impact factor: 14.919

5.  A millifluidic study of cell-to-cell heterogeneity in growth-rate and cell-division capability in populations of isogenic cells of Chlamydomonas reinhardtii.

Authors:  Shima P Damodaran; Stephan Eberhard; Laurent Boitard; Jairo Garnica Rodriguez; Yuxing Wang; Nicolas Bremond; Jean Baudry; Jérôme Bibette; Francis-André Wollman
Journal:  PLoS One       Date:  2015-03-11       Impact factor: 3.240
  5 in total

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