| Literature DB >> 15546727 |
Ramani R Ranatunge1, Richard A Earl, David S Garvey, David R Janero, L Gordon Letts, Allison M Martino, Madhavi G Murty, Stewart K Richardson, David J Schwalb, Delano V Young, Irina S Zemtseva.
Abstract
A series of 3-(2-methoxytetrahydrofuran-2-yl)pyrazoles (4-10) was synthesized. The compounds were evaluated for their ability to inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) activity in human whole blood (HWB). The compound, 5-(4-methanesulfonylphenyl)-3-(2-methoxytetrahydrofuran-2-yl)-1-p-tolyl-1H-pyrazole 5 showed potent and selective COX-2 inhibition (IC50 for COX-1: >100 microM and COX-2: 1.2 microM).Entities:
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Year: 2004 PMID： 15546727 DOI： 10.1016/j.bmcl.2004.09.073
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823