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Literature DB >> 15545983

Stem cells: science, policy, and ethics.

Abstract

Human embryonic stem cells offer the promise of a new regenerative medicine in which damaged adult cells can be replaced with new cells. Research is needed to determine the most viable stem cell lines and reliable ways to promote the differentiation of pluripotent stem cells into specific cell types (neurons, muscle cells, etc). To create new cell lines, it is necessary to destroy preimplantation blastocysts. This has led to an intense debate that threatens to limit embryonic stem cell research. The profound ethical issues raised call for informed, dispassionate debate.

Entities: Disease Species

Keywords: Biomedical and Behavioral Research; Genetics and Reproduction

Mesh：

Year: 2004 PMID： 15545983 PMCID： PMC525749 DOI： 10.1172/JCI23549

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

26 in total

1. Developmental biology. Don't clone humans!

Authors: R Jaenisch; I Wilmut
Journal: Science Date: 2001-03-30 Impact factor: 47.728

Review 2. Nuclear cloning and epigenetic reprogramming of the genome.

Authors: W M Rideout ; K Eggan; R Jaenisch
Journal: Science Date: 2001-08-10 Impact factor: 47.728

3. Dolly's false legacy.

Authors: Ian Wilmut
Journal: Time Date: 1999-01-11

Review 4. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.

Authors: Rudolf Jaenisch; Adrian Bird
Journal: Nat Genet Date: 2003-03 Impact factor: 38.330

5. Somatic cell nuclear transfer.

Authors: I Wilmut; N Beaujean; P A de Sousa; A Dinnyes; T J King; L A Paterson; D N Wells; L E Young
Journal: Nature Date: 2002-10-10 Impact factor: 49.962

6. Directed differentiation of embryonic stem cells into motor neurons.

Authors: Hynek Wichterle; Ivo Lieberam; Jeffery A Porter; Thomas M Jessell
Journal: Cell Date: 2002-08-09 Impact factor: 41.582

Review 7. Transplantation of the islets of Langerhans: new hope for treatment of type 1 diabetes mellitus.

Authors: E H Liu; K C Herold
Journal: Trends Endocrinol Metab Date: 2000-11 Impact factor: 12.015

8. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.

Authors: A M Shapiro; J R Lakey; E A Ryan; G S Korbutt; E Toth; G L Warnock; N M Kneteman; R V Rajotte
Journal: N Engl J Med Date: 2000-07-27 Impact factor: 91.245

9. Embryonic stem cell lines derived from human blastocysts.

Authors: J A Thomson; J Itskovitz-Eldor; S S Shapiro; M A Waknitz; J J Swiergiel; V S Marshall; J M Jones
Journal: Science Date: 1998-11-06 Impact factor: 47.728

10. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.

Authors: Jong-Hoon Kim; Jonathan M Auerbach; José A Rodríguez-Gómez; Iván Velasco; Denise Gavin; Nadya Lumelsky; Sang-Hun Lee; John Nguyen; Rosario Sánchez-Pernaute; Krys Bankiewicz; Ron McKay
Journal: Nature Date: 2002-06-20 Impact factor: 49.962

21 in total

1. The gap between law and ethics in human embryonic stem cell research: overcoming the effect of U.S. federal policy on research advances and public benefit.

Authors: Patrick L Taylor
Journal: Sci Eng Ethics Date: 2005-10 Impact factor: 3.525

Review 2. Stem cells: potential therapeutics for periodontal regeneration.

Authors: Karina Gonzales Silvério; Bruno Braga Benatti; Márcio Zaffalon Casati; Enílson Antônio Sallum; Francisco Humberto Nociti
Journal: Stem Cell Rev Date: 2008 Impact factor: 5.739

3. Human Embryonic Stem Cell Research: Ethical Views of Buddhist, Hindu and Catholic Leaders in Malaysia.

Authors: Mathana Amaris Fiona Sivaraman; Siti Nurani Mohd Noor
Journal: Sci Eng Ethics Date: 2015-06-07 Impact factor: 3.525

Review 4. Tooth-derived stem cells: Update and perspectives.

Authors: Miki Taketomi Saito; Karina Gonzales Silvério; Márcio Zaffalon Casati; Enilson Antonio Sallum; Francisco Humberto Nociti
Journal: World J Stem Cells Date: 2015-03-26 Impact factor: 5.326

5. Ethical Guiding Principles of "Do No Harm" and the "Intention to Save Lives" in relation to Human Embryonic Stem Cell Research: Finding Common Ground between Religious Views and Principles of Medical Ethics.

Authors: Mathana Amaris Fiona Sivaraman
Journal: Asian Bioeth Rev Date: 2019-12-06

6. Using Surplus Embryos and Research Embryos in Stem Cell Research: Ethical Viewpoints of Buddhist, Hindu and Catholic Leaders in Malaysia on the Permissibility of Research.

Authors: Mathana Amaris Fiona Sivaraman
Journal: Sci Eng Ethics Date: 2017-03-09 Impact factor: 3.525

7. Coordinated development of voltage-gated Na+ and K+ currents regulates functional maturation of forebrain neurons derived from human induced pluripotent stem cells.

Authors: Mingke Song; Osama Mohamad; Dongdong Chen; Shan Ping Yu
Journal: Stem Cells Dev Date: 2013-02-01 Impact factor: 3.272