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Literature DB >> 15543937

Effect of dexamethasone on moesin gene expression in rabbit bone marrow stromal cells.

F Cornet¹, O Broux, K Anselme, P Hardouin, J Jeanfils.

Abstract

The influence of dexamethasone on rabbit bone marrow stromal cells differentiation was studied by screening the action of dexamethasone on gene expression. Using differential display, we observed some differential amplifications. The use of five of thirteen different primers combination allowed to identify one or more differential bands. One of them was identified as moesin gene. Real-time PCR confirmed a significant reduction of moesin gene expression following dexamethasone treatment. The decrease of expression for this protein, involved in cytoskeletal organization, could explain the effects of dexamethasone treatment on bone marrow stromal cells differentiation.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15543937 DOI： 10.1023/b:mcbi.0000044309.43612.3b

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

33 in total

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3. Modulation of the effects of glucocorticoids on collagen synthesis in fetal rat calvariae by insulin-like growth factor binding protein-2.

Authors: B E Kream; S Tetradis; D Lafrancis; P M Fall; J H Feyen; L G Raisz
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4. Long-term effects of parathyroid hormone, 1,25-dihydroxyvitamin d(3), and dexamethasone on the cell growth and functional activity of human osteogenic alveolar bone cell cultures.

Authors: M Adelina Costa; M Helena Fernandes
Journal: Pharmacol Res Date: 2000-10 Impact factor: 7.658

5. Human bone cell cultures in biocompatibility testing. Part II: effect of ascorbic acid, beta-glycerophosphate and dexamethasone on osteoblastic differentiation.

Authors: M J Coelho; M H Fernandes
Journal: Biomaterials Date: 2000-06 Impact factor: 12.479

6. The biocompatibility of hydroxyapatite ceramic: a study of retrieved human middle ear implants.

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7. Effects of dexamethasone on proliferation, activity, and cytokine secretion of normal human bone marrow stromal cells: possible mechanisms of glucocorticoid-induced bone loss.

Authors: C H Kim; S L Cheng; G S Kim
Journal: J Endocrinol Date: 1999-09 Impact factor: 4.286

Effect of dexamethasone on moesin gene expression in rabbit bone marrow stromal cells.

Review 1. Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins.

2. Bone sialoprotein (BSP) is a crucial factor for the expression of osteoblastic phenotypes of bone marrow cells cultured on type I collagen matrix.

3. Modulation of the effects of glucocorticoids on collagen synthesis in fetal rat calvariae by insulin-like growth factor binding protein-2.

4. Long-term effects of parathyroid hormone, 1,25-dihydroxyvitamin d(3), and dexamethasone on the cell growth and functional activity of human osteogenic alveolar bone cell cultures.

5. Human bone cell cultures in biocompatibility testing. Part II: effect of ascorbic acid, beta-glycerophosphate and dexamethasone on osteoblastic differentiation.

6. The biocompatibility of hydroxyapatite ceramic: a study of retrieved human middle ear implants.

7. Effects of dexamethasone on proliferation, activity, and cytokine secretion of normal human bone marrow stromal cells: possible mechanisms of glucocorticoid-induced bone loss.

8. Cloning and expression profile of chicken radixin.

9. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members.

10. Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/beta-catenin.

1. Extracts from Plastrum testudinis promote proliferation of rat bone-marrow-derived mesenchymal stem cells.

2. Effect of 5-azacytidine on the protein expression of porcine bone marrow mesenchymal stem cells in vitro.