| Literature DB >> 15533761 |
Sanjeev Krishna1, Anne-Catrin Uhlemann, Richard K Haynes.
Abstract
Artemisinins form the most important class of antimalarial currently available, particularly because they are effective against parasites resistant to almost all the other classes. Their mechanism of action is controversial. Some aspects of this controversy are reviewed here. Whilst there is no clinical resistance yet identified to artemisinins, the potential to examine the relationship between polymorphisms in PfATP6 (a target of artemisinins) in multidrug resistant isolates of Plasmodium falciparum, is also discussed.Entities:
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Year: 2004 PMID： 15533761 DOI： 10.1016/j.drup.2004.07.001
Source DB: PubMed Journal: Drug Resist Updat ISSN： 1368-7646 Impact factor: 18.500