| Literature DB >> 15533028 |
Barbara Vantroyen1, J F Heilier, Agnes Meulemans, Arnold Michels, J P Buchet, Steven Vanderschueren, V Haufroid, Marc Sabbe.
Abstract
A case of a 27-year-old woman who ingested 9000 mg arsenic trioxide (As2O3) is reported. Classical symptoms of an acute arsenicum (As) poisoning such as gastrointestinal cramps, vomiting, diarrhea, ECG changes and disturbed liver function tests were observed. The absorption of the ingested As was minimalized by a continuous gastric irrigation with highly concentrated NaHCO3 and intestinal cleansing with NaHCO3 and polyethyleneglycol was performed. Forced diuresis, BAL (2,3-dimercaptopropanol) and DMSA (meso-2,3-dimercaptosuccinic acid) were started and therapy to enhance the formation of methylated As derivatives, which are potentially less toxic and which can be excreted more easily, was then administered. The patient survived this massive dose of ingested inorganic As with only polyneuropathy one year later.Entities:
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Year: 2004 PMID： 15533028 DOI： 10.1081/clt-200035344
Source DB: PubMed Journal: J Toxicol Clin Toxicol ISSN： 0731-3810