Literature DB >> 15531467

Overexpression of Her2/neu is observed in one third of adult acute lymphoblastic leukemia patients and is associated with chemoresistance in these patients.

Patrice Chevallier, Nelly Robillard, Soraya Wuilleme-Toumi, Françoise Méchinaud, Jean-Luc Harousseau, Hervé Avet-Loiseau.   

Abstract

Among 100 patients with acute lymphoblastic leukemia (ALL), 15 B-ALL patients were found positive for surface Her2/neu expression. The incidence in children was only 3.4% compared to 31% in adults (p=0.001). Considering only adult B-ALL patients (n=38), surface Her2/neu expression was associated with chemoresistance (50% versus 11%, p=0.03) suggesting that it could be a prognostic marker of poor clinical outcome in ALL.

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Year:  2004        PMID： 15531467

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  7 in total

1.  Targeting the epidermal growth factor receptor (HER) family by T cell receptor gene-modified T lymphocytes.

Authors:  Peter Meyerhuber; Heinke Conrad; Lilian Stärck; Matthias Leisegang; Dirk H Busch; Wolfgang Uckert; Helga Bernhard
Journal:  J Mol Med (Berl)       Date:  2010-08-11       Impact factor: 4.599

Review 2.  Molecular imaging of HER2-positive breast cancer: a step toward an individualized 'image and treat' strategy.

Authors:  Jacek Capala; Kirsten Bouchelouche
Journal:  Curr Opin Oncol       Date:  2010-11       Impact factor: 3.645

3.  Combination of chemotherapy and gemtuzumab ozogamicin in adult Philadelphia positive acute lymphoblastic leukemia patient harboring CD33 expression.

Authors:  Patrice Chevallier; Beatrice Mahe; Richard Garand; Pascaline Talmant; Jean-Luc Harousseau; Jacques Delaunay
Journal:  Int J Hematol       Date:  2008-08-01       Impact factor: 2.490

4.  Molecular imaging probes for diagnosis and therapy evaluation of breast cancer.

Authors:  Qingqing Meng; Zheng Li
Journal:  Int J Biomed Imaging       Date:  2013-02-26

5.  Small molecule ErbB inhibitors decrease proliferative signaling and promote apoptosis in philadelphia chromosome-positive acute lymphoblastic leukemia.

Authors:  Mary E Irwin; Laura D Nelson; Janice M Santiago-O'Farrill; Phillip D Knouse; Claudia P Miller; Shana L Palla; Doris R Siwak; Gordon B Mills; Zeev Estrov; Shulin Li; Steven M Kornblau; Dennis P Hughes; Joya Chandra
Journal:  PLoS One       Date:  2013-08-01       Impact factor: 3.240

Review 6.  Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia.

Authors:  Kathrin M Bernt; Stephen P Hunger
Journal:  Front Oncol       Date:  2014-03-25       Impact factor: 6.244

7.  Prognostic relevance of HER2/neu in acute lymphoblastic leukemia and induction of NK cell reactivity against primary ALL blasts by trastuzumab.

Authors:  Sebastian P Haen; Benjamin J Schmiedel; Kathrin Rothfelder; Bastian J Schmied; Truong-Minh Dang; Nora Mirza; Robert Möhle; Lothar Kanz; Wichard Vogel; Helmut R Salih
Journal:  Oncotarget       Date:  2016-03-15
  7 in total

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