| Literature DB >> 15530674 |
G Boland1, J Beran, M Lievens, J Sasadeusz, P Dentico, H Nothdurft, J N Zuckerman, B Genton, R Steffen, L Loutan, J Van Hattum, M Stoffel.
Abstract
The reactogenicity and safety of an experimental hepatitis B (HB) vaccine containing adjuvant system (AS04) was compared with a licensed vaccine in a phase III, single-blind, randomised study in healthy volunteers >or=15 years of age. A total of 1303 subjects were enrolled to receive either two doses of HB-AS04 (0, 6 months) or three doses of the comparator vaccine (0, 1, 6 months). Two doses of HB-AS04 elicited seroprotection rates close to 100% and two-fold higher GMTs than the comparator vaccine. Results showed that both vaccines were well tolerated and the general safety profile of HB-AS04 was similar to that of the comparator vaccine.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15530674 DOI： 10.1016/j.vaccine.2004.06.006
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641