Literature DB >> 20713100

TLR-based immune adjuvants.

Folkert Steinhagen1, Takeshi Kinjo, Christian Bode, Dennis M Klinman.   

Abstract

This work describes the nature and strength of the immune response induced by various Toll-like receptor ligands and their ability to act as vaccine adjuvants. It reviews the various ligands capable of triggering individual TLRs, and then focuses on the efficacy and safety of those agents for which clinical results are available. Published by Elsevier Ltd.

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Year:  2010        PMID: 20713100      PMCID: PMC3000864          DOI: 10.1016/j.vaccine.2010.08.002

Source DB:  PubMed          Journal:  Vaccine        ISSN: 0264-410X            Impact factor:   3.641


  259 in total

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2.  Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs.

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5.  Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity.

Authors:  James W Huleatt; Andrea R Jacobs; Jie Tang; Priyanka Desai; Elizabeth B Kopp; Yan Huang; Langzhou Song; Valerian Nakaar; T J Powell
Journal:  Vaccine       Date:  2006-08-22       Impact factor: 3.641

6.  Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: impact of HLA class I antigen expression on outcome.

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Authors:  Boubacar Traore; Younoussou Koné; Safiatou Doumbo; Didier Doumtabé; Abdramane Traoré; Peter D Crompton; Marko Mircetic; Chiung-Yu Huang; Kassoum Kayentao; Alassane Dicko; Issaka Sagara; Ruth D Ellis; Kazutoyo Miura; Agnes Guindo; Louis H Miller; Ogobara K Doumbo; Susan K Pierce
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8.  CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans.

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Review 9.  TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity.

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10.  Immunoprotective activity and safety of a respiratory syncytial virus vaccine: mucosal delivery of fusion glycoprotein with a CpG oligodeoxynucleotide adjuvant.

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Journal:  J Virol       Date:  2003-12       Impact factor: 5.103

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  168 in total

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2.  Big thinking for adjuvants.

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5.  Systemic and Mucosal Immune Responses to Cryptosporidium-Vaccine Development.

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6.  Dual TLR agonist nanodiscs as a strong adjuvant system for vaccines and immunotherapy.

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7.  Effects of skeletal unloading on the bone marrow antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice.

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8.  The TLR-specific adjuvants R-848 and CpG-B endorse the immunological reaction of neonatal antigen-presenting cells.

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9.  Biomimetic protein nanoparticles facilitate enhanced dendritic cell activation and cross-presentation.

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10.  The next-generation nicotine vaccine: a novel and potent hybrid nanoparticle-based nicotine vaccine.

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