| Literature DB >> 15527760 |
Kei Tominaga1, Chiharu Kondo, Yoshikazu Johmura, Makoto Nishizuka, Masayoshi Imagawa.
Abstract
A novel gene named fad104 (factor for adipocyte differentiation-104), whose expression level quickly increased in the early stage of adipogenesis, was isolated and characterized. The deduced amino acid sequence of fad104 revealed the possible presence of a fibronectin type III domain and transmembrane domain. The expression of fad104 was detected in adipocyte differentiable 3T3-L1 cells but not observed in the non-adipogenic cell line NIH-3T3. Moreover, the ability of 3T3-L1 cells to differentiate declined with the knockdown of fad104 by RNA interference, strongly indicating that fad104 functions as a positive regulator of adipogenesis.Entities:
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Year: 2004 PMID： 15527760 DOI： 10.1016/j.febslet.2004.09.062
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124