Literature DB >> 15524464

Synthesis of alpha-fluorosulfonamides by electrophilic fluorination.

Bryan Hill1, Yong Liu, Scott D Taylor.   

Abstract

Alpha-fluorosulfonamides were prepared by electrophilic fluorination of tertiary sulfonamides using N-fluorobenzenesulfonimide as fluorinating agent and utilizing the dimethoxybenzyl group (DMB) as a new sulfonamide protecting group. Removal of the DMB group with TFA/CH(2)Cl(2) gave primary and secondary alpha-fluorosulfonamides.

Entities:  

Year:  2004        PMID： 15524464     DOI： 10.1021/ol048249z

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents.

Authors:  Ying Zhao; William R Shadrick; Miranda J Wallace; Yinan Wu; Elizabeth C Griffith; Jianjun Qi; Mi-Kyung Yun; Stephen W White; Richard E Lee
Journal:  Bioorg Med Chem Lett       Date:  2016-07-04       Impact factor: 2.823

2.  Highly Selective and Catalytic C-N Bond Cleavage of Tertiary Sulfonamides: Scope and Mechanistic Insight.

Authors:  Aditya Bhattacharya; Pushpendra Mani Shukla; Biswajit Maji
Journal:  ACS Omega       Date:  2021-07-16
  2 in total

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