| Literature DB >> 15523481 |
Klemens Wild1, Mario Halic, Irmgard Sinning, Roland Beckmann.
Abstract
Cotranslational targeting directly couples synthesis of proteins to their translocation across or insertion into membranes. The signal recognition particle (SRP) and its membrane-bound receptor facilitate the targeting of the translation machinery, the ribosome, via recognition of a signal sequence in the nascent peptide chain. By combining structures of free and ribosome-bound SRP we derive a structural model describing the dynamic nature of SRP when it meets the ribosome.Mesh：
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Year: 2004 PMID： 15523481 DOI： 10.1038/nsmb853
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369